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CDK2 and hepatocellular carcinoma are reported together in 4 articles.
Gene
CDK2
- HGNC
- HGNC:1771
32articles
32mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Hepatocellular carcinoma
417articles
417mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Enhancing hepatocellular carcinoma treatment: synergistic cytotoxicity and mechanistic insights of Ramucirumab and 5-Azacytidine combination therapy.
PMID 40397219 | PMCID PMC12102452 | DOI 10.1007/s44446-025-00001-x · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK2 | “Cell cycle arrest was evident through the downregulation of key regulatory genes, including MCM2, MCM3, cyclin B1, and CDK2.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Enhancing hepatocellular carcinoma treatment: synergistic cytotoxicity and mechanistic insights of Ramucirumab and 5-Azacytidine combination therapy.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MCM2 | “Cell cycle arrest was evident through the downregulation of key regulatory genes, including MCM2, MCM3, cyclin B1, and CDK2.” | 0.98 | hgnc_dict_v1 |
| gene | MCM3 | “Cell cycle arrest was evident through the downregulation of key regulatory genes, including MCM2, MCM3, cyclin B1, and CDK2.” | 0.98 | hgnc_dict_v1 |
Anti-cancer activity, and molecular docking of novel hybrid heterocyclic steroids revealed promising anti-hepatocellular carcinoma agent: Implication of cyclin dependent kinase-2 pathway.
PMID 36736802 | DOI 10.1016/j.steroids.2023.109187 · Steroids · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK2 | “Moreover, compound 7 induced apoptosis via upregulating the expression of caspase-3, -8, -9, P53, Bax and inhibiting the expression of BCL2, and CDK2 genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Most notably, compound 7 was the most effective compound against all tested cancer cell lines, especially against HepG2 cell line; therefore, the mode of action of this compound against HCC was investigated.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | BCL2 | “Moreover, compound 7 induced apoptosis via upregulating the expression of caspase-3, -8, -9, P53, Bax and inhibiting the expression of BCL2, and CDK2 genes.” | 0.98 | hgnc_dict_v1 |
Bee venom and its active component Melittin synergistically potentiate the anticancer effect of Sorafenib against HepG2 cells.
PMID 34544028 | DOI 10.1016/j.bioorg.2021.105329 · Bioorganic chemistry · 2021 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK2 | “The computational analysis showed that Mel can bind to and inhibit XIAP, Bcl2, MDM2, CDK2 and MMP12.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “There are current attempts to find a safe substitute or adjuvant for Sorafenib (Sorf), the standard treatment for advanced hepatocellular carcinoma (HCC), as it triggers very harsh side effects and drug-resistance.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | XIAP | “The computational analysis showed that Mel can bind to and inhibit XIAP, Bcl2, MDM2, CDK2 and MMP12.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “The computational analysis showed that Mel can bind to and inhibit XIAP, Bcl2, MDM2, CDK2 and MMP12.” | 0.98 | hgnc_dict_v1 |
Design, Synthesis, Anticancer Evaluation and Docking Studies of Novel Heterocyclic Derivatives Obtained via Reactions Involving Curcumin.
PMID 29890691 | PMCID PMC6099980 | DOI 10.3390/molecules23061398 · Molecules (Basel, Switzerland) · 2018 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK2 | “Cyclin dependent kinase 2 (CDK2), a major cell cycle protein, was identified as a potential molecular target of Curcumin.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “In the present investigation, the newly synthesized products were screened using the MTT colorimetric assay for their in vitro inhibition capacity in two human cancer cell lines (hepatocellular carcinoma (HEPG2) and breast cancer (MCF-7) as well as the normal cell line (human normal melanocyte, HFB4) in comparison to the known anticancer drugs: 5-flurouracil and doxorubicin.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | breast cancer | “In the present investigation, the newly synthesized products were screened using the MTT colorimetric assay for their in vitro inhibition capacity in two human cancer cell lines (hepatocellular carcinoma (HEPG2) and breast cancer (MCF-7) as well as the normal cell line (human normal melanocyte, HFB4) in comparison to the known anticancer drugs: 5-flurouracil and doxorubicin.” | 0.98 | phenotype_alias_lexicon_v2 |