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CDK2 and neurodevelopmental disorder are reported together in 1 article.
Gene
CDK2
- HGNC
- HGNC:1771
32articles
32mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Neurodevelopmental disorder
- HPO
- HP:0012759
450articles
450mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis.
PMID 42164854 | PMCID PMC13186030 | DOI 10.1016/j.isci.2026.115860 · iScience · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK2 | “The titration of PL abundance is coordinated with proper cell cycle entry by Dop1a that restricts nuclear accumulation of CDK2.” | 0.98 | hgnc_dict_v1 |
| phenotype | neurodevelopmental disorder | “DOP1A mutations have been identified in patients with neurodevelopmental disorders (NDDs).” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | AGPAT2 | “A shortage of lysophosphatidic acid (LPA) triggers the rapid localization of Dop1a to the nuclear pore complexes (NPCs), where Dop1a suppresses PL synthesis by binding to AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2), which is also localized at the NPCs.” | 0.98 | hgnc_dict_v1 |
| gene | DOP1A | “DOP1A mutations have been identified in patients with neurodevelopmental disorders (NDDs).” | 0.98 | hgnc_dict_v1 |