Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
CDK2 and prostate cancer are reported together in 3 articles.
Gene
CDK2
- HGNC
- HGNC:1771
32articles
32mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Prostate cancer
218articles
218mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60In silico identification of PPARγ agonists from diffractaic acid analogs in prostate cancer: a comprehensive computational approach.
PMID 40546399 | PMCID PMC12181459 | DOI 10.1007/s13205-025-04376-5 · 3 Biotech · 2025 · 18 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK2 | “The KEGG enrichment analysis indicated that hsa05215: Prostate cancer is one of the most significant PCa enrichment signalling pathways which exhibited 18 protein-protein interactions including PDGFRB, PDGFRA, PPARG, GSK3B, MAP2K1, CREBBP, HSP90AA1, HSP90AB1, CHUK, PIK3CD, BRAF, PIK3CB, MTOR, AR, PIK3CA, PLAU, CDK2, and MAPK1.” | 0.98 | hgnc_dict_v1 |
| phenotype | prostate cancer | “In silico identification of PPARγ agonists from diffractaic acid analogs in prostate cancer: a comprehensive computational approach.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PDGFRB | “The KEGG enrichment analysis indicated that hsa05215: Prostate cancer is one of the most significant PCa enrichment signalling pathways which exhibited 18 protein-protein interactions including PDGFRB, PDGFRA, PPARG, GSK3B, MAP2K1, CREBBP, HSP90AA1, HSP90AB1, CHUK, PIK3CD, BRAF, PIK3CB, MTOR, AR, PIK3CA, PLAU, CDK2, and MAPK1.” | 0.98 | hgnc_dict_v1 |
| gene | PDGFRA | “The KEGG enrichment analysis indicated that hsa05215: Prostate cancer is one of the most significant PCa enrichment signalling pathways which exhibited 18 protein-protein interactions including PDGFRB, PDGFRA, PPARG, GSK3B, MAP2K1, CREBBP, HSP90AA1, HSP90AB1, CHUK, PIK3CD, BRAF, PIK3CB, MTOR, AR, PIK3CA, PLAU, CDK2, and MAPK1.” | 0.98 | hgnc_dict_v1 |
Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer.
PMID 39881138 | PMCID PMC11779938 | DOI 10.1038/s41598-025-85502-4 · Scientific reports · 2025 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK2 | “These miRNAs influence key genes, including FOXO3, NFAT3, PTEN, RHOA, VEGFA, SMAD7, and CDK2, playing significant roles in both tumor suppression and oncogenesis.” | 0.98 | hgnc_dict_v1 |
| phenotype | prostate cancer | “Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | FOXO3 | “These miRNAs influence key genes, including FOXO3, NFAT3, PTEN, RHOA, VEGFA, SMAD7, and CDK2, playing significant roles in both tumor suppression and oncogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “These miRNAs influence key genes, including FOXO3, NFAT3, PTEN, RHOA, VEGFA, SMAD7, and CDK2, playing significant roles in both tumor suppression and oncogenesis.” | 0.98 | hgnc_dict_v1 |
Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence.
PMID 25785833 | PMCID PMC4365013 | DOI 10.1371/journal.pone.0120782 · PloS one · 2015 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK2 | “Cyclin Dependent Kinase-2 Associated Protein-1 (CDK2AP1) is known to be a tumor suppressor that plays a role in cell cycle regulation by sequestering monomeric CDK2, and targeting it for proteolysis.” | 0.98 | hgnc_dict_v1 |
| phenotype | prostate cancer | “CDK2AP1 overexpression was shown to inhibit growth, reduce invasion and increase apoptosis in prostate cancer cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CDK2AP1 | “Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “CDK2AP1 knockdown also resulted in increased mRNA levels of p53, p21, BAX and PUMA and p53 protein levels.” | 0.98 | hgnc_dict_v1 |