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CDK4 and arrhythmia are reported together in 1 article.
Gene
CDK4
- HGNC
- HGNC:1773
30articles
30mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Arrhythmia
555articles
555mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure.
PMID 35061545 | PMCID PMC9038650 | DOI 10.1161/CIRCULATIONAHA.121.057641 · Circulation · 2022 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK4 | “Our previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin-dependent kinase 1], CDK4 [cyclin-dependent kinase 4], CCNB [cyclin B1], and CCND [cyclin D1]) promotes cardiomyocyte proliferation in 15% to 20% of infected cardiomyocytes in vitro and in vivo and improves cardiac function after myocardial infarction in mice.” | 0.98 | hgnc_dict_v1 |
| phenotype | arrhythmia | “At 4 months after treatment, rats that received TNNT2-4Fpolycistronic-NIL still showed a sustained improvement in cardiac function and no obvious development of cardiac arrhythmias or systemic tumorigenesis (n=10/group).” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CDK1 | “Our previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin-dependent kinase 1], CDK4 [cyclin-dependent kinase 4], CCNB [cyclin B1], and CCND [cyclin D1]) promotes cardiomyocyte proliferation in 15% to 20% of infected cardiomyocytes in vitro and in vivo and improves cardiac function after myocardial infarction in mice.” | 0.98 | hgnc_dict_v1 |
| gene | TNNT2 | “Transient overexpression of 4F, specifically in cardiomyocytes, was achieved using a polycistronic nonintegrating lentivirus (NIL) encoding 4F; each is driven by a TNNT2 (cardiac troponin T isoform 2) promoter (TNNT2-4Fpolycistronic-NIL).” | 0.98 | hgnc_dict_v1 |