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CDK4 and prostate cancer are reported together in 2 articles.
Gene
CDK4
- HGNC
- HGNC:1773
30articles
30mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Prostate cancer
218articles
218mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 603-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells.
PMID 39985578 | DOI 10.1007/s00210-025-03899-1 · Naunyn-Schmiedeberg's archives of pharmacology · 2025 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK4 | “AKBA was also found to induce G0/G1 arrest which was substantiated by reduced cyclin D1 and CDK4 expression levels concomitantly with increased expression of p21 and p27 genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | prostate cancer | “3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells.” | 0.98 | phenotype_alias_lexicon_v2 |
Carvacrol instigates intrinsic and extrinsic apoptosis with abrogation of cell cycle progression in cervical cancer cells: Inhibition of Hedgehog/GLI signaling cascade.
PMID 36712982 | PMCID PMC9874127 | DOI 10.3389/fchem.2022.1064191 · Frontiers in chemistry · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDK4 | “CAR efficiently inhibited the growth of cervical cancer cells via arresting the cell cycle at G0/G1 phase and modulated the gene expression of related proteins (p21, p27, cyclin D1 and CDK4).” | 0.98 | hgnc_dict_v1 |
| phenotype | prostate cancer | “Moreover, our previous reports have established that carvacrol (CAR) inhibited the proliferation of prostate cancer cells via inhibiting the Notch signaling pathway and thus, it was rational to explore its antiproliferative effects in cervical cancer cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SMO | “Moreover, CAR inhibited the HH/GLI signaling pathway by down regulating the expression of SMO, PTCH and GLI1 proteins in cervical carcinoma cells.” | 0.98 | hgnc_dict_v1 |
| gene | GLI1 | “Moreover, CAR inhibited the HH/GLI signaling pathway by down regulating the expression of SMO, PTCH and GLI1 proteins in cervical carcinoma cells.” | 0.98 | hgnc_dict_v1 |