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CDKN2A and diabetes mellitus are reported together in 5 articles.
Gene
CDKN2A
- HGNC
- HGNC:1787
48articles
48mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
5 records shown · first 60Association Between CDKAL1, HHEX, CDKN2A/2B and IGF2BP2 Gene Polymorphisms and Susceptibility to Type 2 Diabetes in Uttarakhand, India.
PMID 33442279 | PMCID PMC7797276 | DOI 10.2147/DMSO.S284998 · Diabetes, metabolic syndrome and obesity : targets and therapy · 2021 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDKN2A | “Association Between CDKAL1, HHEX, CDKN2A/2B and IGF2BP2 Gene Polymorphisms and Susceptibility to Type 2 Diabetes in Uttarakhand, India.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Association Between CDKAL1, HHEX, CDKN2A/2B and IGF2BP2 Gene Polymorphisms and Susceptibility to Type 2 Diabetes in Uttarakhand, India.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CDKAL1 | “Association Between CDKAL1, HHEX, CDKN2A/2B and IGF2BP2 Gene Polymorphisms and Susceptibility to Type 2 Diabetes in Uttarakhand, India.” | 0.98 | hgnc_dict_v1 |
| gene | HHEX | “Association Between CDKAL1, HHEX, CDKN2A/2B and IGF2BP2 Gene Polymorphisms and Susceptibility to Type 2 Diabetes in Uttarakhand, India.” | 0.98 | hgnc_dict_v1 |
Genetics and genomics studies in type 2 diabetes: A brief review of the current scenario in the Arab region.
PMID 31336532 | DOI 10.1016/j.dsx.2019.03.017 · Diabetes & metabolic syndrome · 2019 · 18 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDKN2A | “Studies from Egypt, Iraq, Jordan, Oman, Qatar, Saudi Arabia, Tunisia, and United Arab Emirates had been explored studying the associations of GIPR, ADIPOQ, FTO, (GRCh38.p12), MLXIP, AKNAD1, KCNJ11 CDKAL1, CDKN2A/2B, TCF7L2, ACE, SNAP25, ELMO1, VDR, KCTD8, GABRA4 and PRKD1 genes with T2D development.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Genetics and genomics studies in type 2 diabetes: A brief review of the current scenario in the Arab region.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | GIPR | “Studies from Egypt, Iraq, Jordan, Oman, Qatar, Saudi Arabia, Tunisia, and United Arab Emirates had been explored studying the associations of GIPR, ADIPOQ, FTO, (GRCh38.p12), MLXIP, AKNAD1, KCNJ11 CDKAL1, CDKN2A/2B, TCF7L2, ACE, SNAP25, ELMO1, VDR, KCTD8, GABRA4 and PRKD1 genes with T2D development.” | 0.98 | hgnc_dict_v1 |
| gene | ADIPOQ | “Studies from Egypt, Iraq, Jordan, Oman, Qatar, Saudi Arabia, Tunisia, and United Arab Emirates had been explored studying the associations of GIPR, ADIPOQ, FTO, (GRCh38.p12), MLXIP, AKNAD1, KCNJ11 CDKAL1, CDKN2A/2B, TCF7L2, ACE, SNAP25, ELMO1, VDR, KCTD8, GABRA4 and PRKD1 genes with T2D development.” | 0.98 | hgnc_dict_v1 |
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
PMID 24296717 | PMCID PMC4030103 | DOI 10.2337/db13-0949 · Diabetes · 2014 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDKN2A | “A fourth cluster (TCF7L2, SLC30A8, HHEX/IDE, CDKAL1, CDKN2A/2B) was defined by loci influencing insulin processing and secretion without a detectable change in fasting glucose levels.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | PPARG | “The first cluster (PPARG, KLF14, IRS1, GCKR) was characterized by primary effects on insulin sensitivity.” | 0.98 | hgnc_dict_v1 |
| gene | KLF14 | “The first cluster (PPARG, KLF14, IRS1, GCKR) was characterized by primary effects on insulin sensitivity.” | 0.98 | hgnc_dict_v1 |
Assessing the contribution of 38 genetic loci to the risk of type 2 diabetes in the Saudi Arabian Population.
PMID 23448427 | DOI 10.1111/cen.12187 · Clinical endocrinology · 2014 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDKN2A | “CONCLUSIONS: We have shown for the first time that variants at WFS1, JAZF1, SLC30A8, CDKN2A/B, TCF7L2, KCNQ1, HMG20A, HNF4A and DUSP9 are associated with T2D in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Assessing the contribution of 38 genetic loci to the risk of type 2 diabetes in the Saudi Arabian Population.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HNF4A | “The effect sizes of these loci were comparable to those previously identified in other populations with the exception of HNF4A, which showed a trend for larger effect size in our study population (OR = 1·27) compared to that reported in South Asian populations (OR = 1·09; I(2) = 65·9).” | 0.98 | hgnc_dict_v1 |
| gene | SLC30A8 | “Analysis of a subgroup of subjects with BMI≤30 resulted in two additional loci (SLC30A8; P = 0·03, HMG20A; P = 0·02) showing significant association with T2D.” | 0.98 | hgnc_dict_v1 |
ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.
PMID 23458876 | DOI 10.1016/j.gene.2013.02.017 · Gene · 2013 · 20 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDKN2A | “Meanwhile PPARG-2 Pro12Ala, CDKN2A/2B rs10811661, IGF2BP2 rs4402960, HHEX rs7923837, CDKAL1 rs7754840, EXT2 rs1113132 and SLC30A8 rs13266634 were found to have no significant association with T2D among Arabs.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | ACE | “ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | MTHFR | “ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.” | 0.98 | hgnc_dict_v1 |