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CDX2 and gastric cancer are reported together in 1 article.
Gene
CDX2
- HGNC
- HGNC:1806
11articles
11mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Gastric cancer
106articles
106mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Anti-cancer activity of guggulsterone by modulating apoptotic markers: a systematic review and meta-analysis.
PMID 37201024 | PMCID PMC10185795 | DOI 10.3389/fphar.2023.1155163 · Frontiers in pharmacology · 2023 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDX2 | “Furthermore, Guggulsterone reduces the production of inflammatory markers, such as CDX2 and COX-2.” | 0.98 | hgnc_dict_v1 |
| phenotype | gastric cancer | “A total of 40 articles were included in the systematic review and of them, 23 articles were included in the meta-analysis.The cancerous cell lines used in the studies were for pancreatic cancer, hepatocellular carcinoma, head and neck squamous cell carcinoma, cholangiocarcinoma, oesophageal adenocarcinoma, prostrate cancer, colon cancer, breast cancer, gut derived adenocarcinoma, gastric cancer, colorectal cancer, bladder cancer, glioblastoma, histiocytic leukemia, acute myeloid leukemia and non-small cell lung cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | STAT3 | “In vitro studies reveal that Guggulsterone inhibits and suppresses the proliferation of an extensive range of cancer cells by decreasing intrinsic mitochondrial apoptosis, regulating NF-kB/STAT3/β-Catenin/PI3K/Akt/CHOP pathway, modulating the expression of associated genes/proteins, and inhibiting angiogenesis.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “A total of 40 articles were included in the systematic review and of them, 23 articles were included in the meta-analysis.The cancerous cell lines used in the studies were for pancreatic cancer, hepatocellular carcinoma, head and neck squamous cell carcinoma, cholangiocarcinoma, oesophageal adenocarcinoma, prostrate cancer, colon cancer, breast cancer, gut derived adenocarcinoma, gastric cancer, colorectal cancer, bladder cancer, glioblastoma, histiocytic leukemia, acute myeloid leukemia and non-small cell lung cancer.” | 0.98 | phenotype_alias_lexicon_v2 |