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CFTR and breast cancer are reported together in 1 article.
Gene
CFTR
- HGNC
- HGNC:1884
54articles
54mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
cystic fibrosis 50infertility 4Duchenne muscular dystrophy 2primary ciliary dyskinesia 2spinal muscular atrophy 2Crohn disease 1breast cancer 1dyslipidemia 1
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Association of ATP-binding cassette transporter genomic alterations and expressions with patient survival in breast and prostate cancer.
PMID 40641097 | PMCID PMC12245978 | DOI 10.14814/phy2.70460 · Physiological reports · 2025 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CFTR | “DepMap analysis revealed the overall dependency of cancer cell lines on ABC transporter genes such as ABCG2, ABCG1, ABCC4, ABCA2, ABCA3, ABCC2, ABCC3, ABCC6, ABCC7 (CFTR), and ABCC9, with ABCC6 and ABCC7 showing notably high dependence.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Data from the cBioPortal for Cancer Genomics, incorporating multiple phase-3 randomized clinical trials, identified genomic alterations including amplifications, deletions, and mutations in breast cancer patients (32 studies, 15,404 samples) and prostate cancer patients (29 studies, 13,857 samples).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ABCG2 | “DepMap analysis revealed the overall dependency of cancer cell lines on ABC transporter genes such as ABCG2, ABCG1, ABCC4, ABCA2, ABCA3, ABCC2, ABCC3, ABCC6, ABCC7 (CFTR), and ABCC9, with ABCC6 and ABCC7 showing notably high dependence.” | 0.98 | hgnc_dict_v1 |
| gene | ABCG1 | “DepMap analysis revealed the overall dependency of cancer cell lines on ABC transporter genes such as ABCG2, ABCG1, ABCC4, ABCA2, ABCA3, ABCC2, ABCC3, ABCC6, ABCC7 (CFTR), and ABCC9, with ABCC6 and ABCC7 showing notably high dependence.” | 0.98 | hgnc_dict_v1 |