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CTLA4 and breast cancer are reported together in 4 articles.
Gene
CTLA4
- HGNC
- HGNC:2505
23articles
23mentions
8variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 4systemic lupus erythematosus 3atopic dermatitis 1hemophilia 1hepatitis C 1leukemia 1lung cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Evaluation of PD-L1 Expression and Systemic Inflammatory Blood Cell Ratios as Prognosticators in Advanced Lung, Breast and Head and Neck Cancers.
PMID 42279401 | PMCID PMC13255956 | DOI 10.3390/cancers18111819 · Cancers · 2026 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CTLA4 | “Bioinformatics analysis identified several PD-L1-interacting genes, including PD-1, CTLA4 and PTPN and demonstrated strong positive correlations between PD-L1 expression and the infiltration of CD8+ T cells, neutrophils and dendritic cells across the analysed malignancies.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “RESULTS: PD-L1 positivity (≥1%) was observed in 56.75% of lung cancer cases, 44% of breast cancer cases and 92.85% of head and neck cancer cases.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | lung cancer | “RESULTS: PD-L1 positivity (≥1%) was observed in 56.75% of lung cancer cases, 44% of breast cancer cases and 92.85% of head and neck cancer cases.” | 0.98 | phenotype_alias_lexicon_v2 |
Exploring the landscape of autoimmune disorder-associated genes and their impact on immune microenvironment in breast cancer patients.
PMID 40672619 | PMCID PMC12261193 | DOI 10.62347/EANH4082 · American journal of translational research · 2025 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CTLA4 | “Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Exploring the landscape of autoimmune disorder-associated genes and their impact on immune microenvironment in breast cancer patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CXCR4 | “Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.” | 0.98 | hgnc_dict_v1 |
Herpesvirus entry mediator as a potential biomarker in breast cancer compared with conventional cytotoxic T‑lymphocyte‑associated antigen 4.
PMID 37560313 | PMCID PMC10407466 | DOI 10.3892/br.2023.1638 · Biomedical reports · 2023 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CTLA4 | “A similar finding was observed for cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; FC=1.47 and P=0.035).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Herpesvirus entry mediator as a potential biomarker in breast cancer compared with conventional cytotoxic T‑lymphocyte‑associated antigen 4.” | 0.98 | phenotype_alias_lexicon_v2 |
Signal peptide missense variant in cancer-brake gene CTLA4 and breast cancer outcomes.
PMID 32044407 | DOI 10.1016/j.gene.2020.144435 · Gene · 2020 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CTLA4 | “Signal peptide missense variant in cancer-brake gene CTLA4 and breast cancer outcomes.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Signal peptide missense variant in cancer-brake gene CTLA4 and breast cancer outcomes.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | c.49A>G | “Hence, this study is designed to assess the association of CTLA4 (c.49A>G, rs231775) variant with the outcome of breast carcinoma.” | 0.95 | hgvs_regex_v1 |
| variant | rs231775 | “Hence, this study is designed to assess the association of CTLA4 (c.49A>G, rs231775) variant with the outcome of breast carcinoma.” | 0.90 | hgvs_regex_v1 |