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CTLA4 and systemic lupus erythematosus are reported together in 3 articles.
Gene
CTLA4
- HGNC
- HGNC:2505
23articles
23mentions
8variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 4systemic lupus erythematosus 3atopic dermatitis 1hemophilia 1hepatitis C 1leukemia 1lung cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Systemic lupus erythematosus
191articles
191mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60The expression of pruritus-associated genes in seven skin diseases: Evidence from microarray.
PMID 41081460 | DOI 10.1111/jdv.70109 · Journal of the European Academy of Dermatology and Venereology : JEADV · 2026 · 18 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CTLA4 | “We found the top differentially upregulated pruritus-associated genes were CLEC7A, IL7R and TNFRSF1B in acne; HLA-DRA, IL2RG and POU2AF1 in alopecia areata; IL2RG, PLEC and CTLA4 in atopic dermatitis; CLEC7A, IL7R and LIPA in cutaneous lupus erythematosus; HLA-DRA, ABCA12 and IL7R in lichen planus; CLEC7A, TGM1 and SDR9C7 in psoriasis and IL7R, HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5/LOC105369230 and POU2AF1 in rosacea.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “BACKGROUND: Pruritus may accompany different skin diseases including atopic dermatitis, lichen planus, psoriasis, cutaneous lupus erythematosus, acne, alopecia areata and rosacea.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CLEC7A | “We found the top differentially upregulated pruritus-associated genes were CLEC7A, IL7R and TNFRSF1B in acne; HLA-DRA, IL2RG and POU2AF1 in alopecia areata; IL2RG, PLEC and CTLA4 in atopic dermatitis; CLEC7A, IL7R and LIPA in cutaneous lupus erythematosus; HLA-DRA, ABCA12 and IL7R in lichen planus; CLEC7A, TGM1 and SDR9C7 in psoriasis and IL7R, HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5/LOC105369230 and POU2AF1 in rosacea.” | 0.98 | hgnc_dict_v1 |
| gene | IL7R | “We found the top differentially upregulated pruritus-associated genes were CLEC7A, IL7R and TNFRSF1B in acne; HLA-DRA, IL2RG and POU2AF1 in alopecia areata; IL2RG, PLEC and CTLA4 in atopic dermatitis; CLEC7A, IL7R and LIPA in cutaneous lupus erythematosus; HLA-DRA, ABCA12 and IL7R in lichen planus; CLEC7A, TGM1 and SDR9C7 in psoriasis and IL7R, HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5/LOC105369230 and POU2AF1 in rosacea.” | 0.98 | hgnc_dict_v1 |
Cytotoxic T-lymphocyte associated protein 4 (CTLA4) polymorphisms are linked to systemic lupus erythematosus: an updated meta-analysis.
PMID 36597619 | DOI 10.1080/02648725.2022.2163817 · Biotechnology & genetic engineering reviews · 2023 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CTLA4 | “Cytotoxic T-lymphocyte associated protein 4 (CTLA4) polymorphisms are linked to systemic lupus erythematosus: an updated meta-analysis.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Cytotoxic T-lymphocyte associated protein 4 (CTLA4) polymorphisms are linked to systemic lupus erythematosus: an updated meta-analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
Association of AIRE (rs2075876), but not CTLA4 (rs231775) polymorphisms with systemic lupus erythematosus.
PMID 33122082 | DOI 10.1016/j.gene.2020.145270 · Gene · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CTLA4 | “Association of AIRE (rs2075876), but not CTLA4 (rs231775) polymorphisms with systemic lupus erythematosus.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Association of AIRE (rs2075876), but not CTLA4 (rs231775) polymorphisms with systemic lupus erythematosus.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | AIRE | “Association of AIRE (rs2075876), but not CTLA4 (rs231775) polymorphisms with systemic lupus erythematosus.” | 0.98 | hgnc_dict_v1 |
| variant | rs2075876 | “Association of AIRE (rs2075876), but not CTLA4 (rs231775) polymorphisms with systemic lupus erythematosus.” | 0.90 | hgvs_regex_v1 |