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CXCL1 and Crohn disease are reported together in 1 article.
Gene
CXCL1
- HGNC
- HGNC:4602
17articles
17mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Crohn disease
435articles
435mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Exploring the dual role of Mangifera indica L. in regulating immune response and pain persistence in inflammatory bowel disease.
PMID 40389041 | DOI 10.1016/j.phrs.2025.107773 · Pharmacological research · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL1 | “MIE treatment administered either simultaneously or post-DNBS induction, significantly reduced pathogenic Th1 and Th17 cell infiltration, along with pro-inflammatory cytokines (IL-1β, TNF-α) and chemokines (CXCL1, CXCL2), though histopathology showed no significant improvements in tissue healing.” | 0.98 | hgnc_dict_v1 |
| phenotype | Crohn disease | “Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is characterized by chronic intestinal inflammation and immune dysregulation, driven mainly by Th1 and Th17 cells and sustained by pro-inflammatory cyto-chemokines.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CXCL2 | “MIE treatment administered either simultaneously or post-DNBS induction, significantly reduced pathogenic Th1 and Th17 cell infiltration, along with pro-inflammatory cytokines (IL-1β, TNF-α) and chemokines (CXCL1, CXCL2), though histopathology showed no significant improvements in tissue healing.” | 0.98 | hgnc_dict_v1 |
| phenotype | inflammatory bowel disease | “Exploring the dual role of Mangifera indica L. in regulating immune response and pain persistence in inflammatory bowel disease.” | 0.98 | phenotype_alias_lexicon_v2 |