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CXCL12 and breast cancer are reported together in 5 articles.
Gene
CXCL12
- HGNC
- HGNC:10672
18articles
18mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
5 records shown · first 60CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.
PMID 37290620 | DOI 10.1016/j.envres.2023.116335 · Environmental research · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL12 | “CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CXCR4 | “CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.” | 0.98 | hgnc_dict_v1 |
Antimetastatic Activity of Lactoferrin-Coated Mesoporous Maghemite Nanoparticles in Breast Cancer Enabled by Combination Therapy.
PMID 33463159 | DOI 10.1021/acsbiomaterials.0c00086 · ACS biomaterials science & engineering · 2020 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL12 | “Indeed, chemo/MF/PTT combination therapy exhibited the most reduction in metastatic activity of breast cancer based on controlling C-X-C motif chemokine ligand 12 (CXCL12) and chemokine receptor 7 (CXCR7) mRNA expression.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Antimetastatic Activity of Lactoferrin-Coated Mesoporous Maghemite Nanoparticles in Breast Cancer Enabled by Combination Therapy.” | 0.98 | phenotype_alias_lexicon_v2 |
CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors.
PMID 30993013 | PMCID PMC6459874 | DOI 10.1038/s41420-019-0169-3 · Cell death discovery · 2019 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL12 | “Interestingly, significant positive correlation between CXCR7 and CXCL12 gene expression (Pearson = 0.3, p = 2.0 × 10-16) was observed in breast cancer patients, suggesting a biological role for the CXCR7/CXCL12 genetic circuit in breast cancer biology.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors.” | 0.98 | phenotype_alias_lexicon_v2 |
Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway.
PMID 27097161 | PMCID PMC4838272 | DOI 10.1371/journal.pone.0153155 · PloS one · 2016 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL12 | “In addition, CIP significantly downregulated the CXCL12 induced motility of breast cancer cells and molecular docking calculations revealed that all compounds bind to Akt2 kinase with high docking scores compared to the library of previously reported Akt2 inhibitors.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway.” | 0.98 | phenotype_alias_lexicon_v2 |
Posttranscriptional control of the chemokine receptor CXCR4 expression in cancer cells.
PMID 24692066 | PMCID PMC4146410 | DOI 10.1093/carcin/bgu080 · Carcinogenesis · 2014 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL12 | “HuR silencing led to decreased CXCR4 mRNA stability and expression, and significant reduction in migration of the cells toward the CXCR4 ligand, CXCL12.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “In the invasive breast cancer phenotype, aberrant expression of CXCR4 is linked to both TTP deficiency and HuR overexpression.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CXCR4 | “Posttranscriptional control of the chemokine receptor CXCR4 expression in cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | ZFP36 | “Here, we find that CXCR4 harbors AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR) that bind and respond to the RNA-binding proteins, tristetraprolin (TTP/ZFP36) and HuR (ELAVL1).” | 0.98 | hgnc_dict_v1 |