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Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
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CXCL12 and obesity are reported together in 1 article.
Gene
CXCL12
- HGNC
- HGNC:10672
18articles
18mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60PCR array and protein array studies demonstrate that IL-1β (interleukin-1β) stimulates the expression and secretion of multiple cytokines and chemokines in human adipocytes.
PMID 26471721 | DOI 10.3109/13813455.2015.1087034 · Archives of physiology and biochemistry · 2015 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL12 | “IL-1β stimulated the expression of >30 cytokine/chemokine genes on the arrays; 15 showed >100-fold increases in mRNA at 4 or 24 h including CSF3, CXCL1, CXCL2, CXCL12 and IL8.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “IL-1β is likely to play a substantial role in stimulating the inflammatory response in human adipocytes in obesity.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CSF3 | “IL-1β stimulated the expression of >30 cytokine/chemokine genes on the arrays; 15 showed >100-fold increases in mRNA at 4 or 24 h including CSF3, CXCL1, CXCL2, CXCL12 and IL8.” | 0.98 | hgnc_dict_v1 |
| gene | CXCL1 | “IL-1β stimulated the expression of >30 cytokine/chemokine genes on the arrays; 15 showed >100-fold increases in mRNA at 4 or 24 h including CSF3, CXCL1, CXCL2, CXCL12 and IL8.” | 0.98 | hgnc_dict_v1 |