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CXCL5 and COVID-19 are reported together in 1 article.
Gene
CXCL5
- HGNC
- HGNC:10642
9articles
9mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
COVID-19
1,317articles
1,317mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages.
PMID 34248968 | PMCID PMC8261299 | DOI 10.3389/fimmu.2021.683800 · Frontiers in immunology · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL5 | “For this purpose, we treated PMA-differentiated THP-1 human macrophages with SARS-CoV-2 S protein and measured the induction of inflammatory mediators including IL6, TNFα, IL8, CXCL5, and MIP1a.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Thus, activation of ACE2 may be a potential anti-inflammatory therapeutic strategy to eliminate the development of cytokine storm observed in COVID-19 patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ACE2 | “SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “The results were confirmed in primary human peripheral monocytic cells (PBMCs) and isolated CD14+ monocytes.” | 0.98 | hgnc_dict_v1 |