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CXCL8 and Crohn disease are reported together in 1 article.
Gene
CXCL8
- HGNC
- HGNC:6025
24articles
24mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 4Crohn disease 1MERS 1atopic dermatitis 1diabetes mellitus 1hepatocellular carcinoma 1inflammatory bowel disease 1renal failure 1
Reported variants (articles · ClinVar status)
Phenotype
Crohn disease
435articles
435mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60AQP9 and IFITM1 as drivers of immune infiltration and tumor progression in IBD-associated colorectal cancer: from computational insights to experimental validation.
PMID 40622593 | DOI 10.1007/s00210-025-04362-x · Naunyn-Schmiedeberg's archives of pharmacology · 2026 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL8 | “XGBoost classification achieved an overall accuracy of 88% (IBD: 71%, controls: 93%), with SHAP analysis pinpointing nine key genes, including AQP9, CXCL8, IFITM1, and ITGA5.” | 0.98 | hgnc_dict_v1 |
| phenotype | Crohn disease | “RNA-sequencing data (GSE165512) from 170 samples-84 Crohn's disease (CD), 40 ulcerative colitis (UC), and 46 controls-were normalized using R.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | AQP9 | “AQP9 and IFITM1 as drivers of immune infiltration and tumor progression in IBD-associated colorectal cancer: from computational insights to experimental validation.” | 0.98 | hgnc_dict_v1 |
| gene | IFITM1 | “AQP9 and IFITM1 as drivers of immune infiltration and tumor progression in IBD-associated colorectal cancer: from computational insights to experimental validation.” | 0.98 | hgnc_dict_v1 |