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CXCL8 and atopic dermatitis are reported together in 1 article.
Gene
CXCL8
- HGNC
- HGNC:6025
24articles
24mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 4Crohn disease 1MERS 1atopic dermatitis 1diabetes mellitus 1hepatocellular carcinoma 1inflammatory bowel disease 1renal failure 1
Reported variants (articles · ClinVar status)
Phenotype
Atopic dermatitis
132articles
132mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Topical Anti-Inflammatory Effects of Quercetin Glycosides on Atopic Dermatitis-Like Lesions: Influence of the Glycone Type on Efficacy and Skin Absorption.
PMID 39808370 | PMCID PMC12596333 | DOI 10.1007/s10753-025-02236-1 · Inflammation · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL8 | “The glycosides effectively reduced the overexpression of proinflammatory effectors such as interleukin (IL)-6, chemokine (C-X-C motif) ligand (CXCL)1, CXCL8, regulated upon activation normal T cell expressed and secreted (RANTES), and thymus and activation-regulated chemokine (TARC) in the activated keratinocytes.” | 0.98 | hgnc_dict_v1 |
| phenotype | atopic dermatitis | “Atopic dermatitis (AD) is a multifaceted inflammatory skin condition characterized by the involvement of various cell types, such as keratinocytes, macrophages, neutrophils, and mast cells.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CCL5 | “Isoquercitrin (but not quercitrin and rutin) could arrest the upregulated IL-6 and CCL5 in the macrophage model.” | 0.98 | hgnc_dict_v1 |