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CXCL8 and diabetes mellitus are reported together in 1 article.
Gene
CXCL8
- HGNC
- HGNC:6025
24articles
24mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 4Crohn disease 1MERS 1atopic dermatitis 1diabetes mellitus 1hepatocellular carcinoma 1inflammatory bowel disease 1renal failure 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Natural Compounds from Hatikana Extract Potentiate Antidiabetic Actions as Displayed by In Vivo Assays and Verified by Network Pharmacological Tools.
PMID 34725640 | PMCID PMC8557063 | DOI 10.1155/2021/6978450 · BioMed research international · 2021 · 27 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL8 | “Oleanolic acid interacted with the proteins AKR1B10, CASP3, CASP8, CYP1A2, CYP1A2, HMGB1, NAMPT, NFE2L2, NQO1, PPARA, PTGIR, TOP1, TOP2A, UGT2B10, and UGT2B11 and stigmasterol with ABCA1, ABCG5, ABCG8, CTSE, HMGCR, IL10, CXCL8, NR1H2, NR1H3, SLCO1B1, SREBF2, and TNF.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Pathway analysis identified 31 KEGG metabolic, signaling, and immunogenic pathways associated with diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | SOD1 | “Following intervention, blood serum was examined for biochemical markers, and liver tissue was investigated for the mRNA expression of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD1) by RTPCR analysis.” | 0.98 | hgnc_dict_v1 |
| gene | AKR1B10 | “Oleanolic acid interacted with the proteins AKR1B10, CASP3, CASP8, CYP1A2, CYP1A2, HMGB1, NAMPT, NFE2L2, NQO1, PPARA, PTGIR, TOP1, TOP2A, UGT2B10, and UGT2B11 and stigmasterol with ABCA1, ABCG5, ABCG8, CTSE, HMGCR, IL10, CXCL8, NR1H2, NR1H3, SLCO1B1, SREBF2, and TNF.” | 0.98 | hgnc_dict_v1 |