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CXCL8 and hepatocellular carcinoma are reported together in 1 article.
Gene
CXCL8
- HGNC
- HGNC:6025
24articles
24mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 4Crohn disease 1MERS 1atopic dermatitis 1diabetes mellitus 1hepatocellular carcinoma 1inflammatory bowel disease 1renal failure 1
Reported variants (articles · ClinVar status)
Phenotype
Hepatocellular carcinoma
417articles
417mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Elucidation of molecular mechanisms, pathways, and diseases modulated by arsenicals through toxogenomics and multi-omics analysis.
PMID 39531826 | DOI 10.1016/j.jtemb.2024.127561 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2024 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCL8 | “The most frequently interacting genes were HMOX1, CAT, NFE2L2, CASP3, MAPK1, CXCL8, PARP1, TNF, and PYGM.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Analysis of TCGA pan-cancer data revealed that 46 % of hepatocellular carcinoma patients exhibited alterations in the genes HMOX1, CAT, NFE2L2, CASP3, MAPK1, CXCL8, PARP1, TNF, and PYGM, suggesting their significant role in the development of this disease.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | HMOX1 | “The most frequently interacting genes were HMOX1, CAT, NFE2L2, CASP3, MAPK1, CXCL8, PARP1, TNF, and PYGM.” | 0.98 | hgnc_dict_v1 |
| gene | NFE2L2 | “The most frequently interacting genes were HMOX1, CAT, NFE2L2, CASP3, MAPK1, CXCL8, PARP1, TNF, and PYGM.” | 0.98 | hgnc_dict_v1 |