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CXCR3 and neurodevelopmental disorder are reported together in 3 articles.
Gene
CXCR3
- HGNC
- HGNC:4540
14articles
14mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Neurodevelopmental disorder
- HPO
- HP:0012759
450articles
450mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Immune Alterations in CD8+ T Cells Are Associated with Neuronal C-C and C-X-C Chemokine Receptor Regulation Through Adenosine A2A Receptor Signaling in a BTBR T+ Itpr3tf/J Autistic Mouse Model.
PMID 28421534 | DOI 10.1007/s12035-017-0548-9 · Molecular neurobiology · 2018 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCR3 | “In this study, we examined the effects of A2A receptor antagonist SCH5826 (SCH) and A2A receptor agonist CGS21680 (CGS) on C-C and C-X-C chemokine receptors (CCR3, CCR4, CCR5, CCR6, CCR7, CXCR3, CXCR4, and CXCR5) on splenic CD8+ T cells in the BTBR autistic mouse model.” | 0.98 | hgnc_dict_v1 |
| phenotype | neurodevelopmental disorder | “Associative studies on a range of neurodevelopmental disorders have identified relationships between behavioral deficits and immune system function.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CCR3 | “In this study, we examined the effects of A2A receptor antagonist SCH5826 (SCH) and A2A receptor agonist CGS21680 (CGS) on C-C and C-X-C chemokine receptors (CCR3, CCR4, CCR5, CCR6, CCR7, CXCR3, CXCR4, and CXCR5) on splenic CD8+ T cells in the BTBR autistic mouse model.” | 0.98 | hgnc_dict_v1 |
| gene | CCR4 | “In this study, we examined the effects of A2A receptor antagonist SCH5826 (SCH) and A2A receptor agonist CGS21680 (CGS) on C-C and C-X-C chemokine receptors (CCR3, CCR4, CCR5, CCR6, CCR7, CXCR3, CXCR4, and CXCR5) on splenic CD8+ T cells in the BTBR autistic mouse model.” | 0.98 | hgnc_dict_v1 |
Downregulation in Helios transcription factor signaling is associated with immune dysfunction in blood leukocytes of autistic children.
PMID 29698674 | DOI 10.1016/j.pnpbp.2018.04.011 · Progress in neuro-psychopharmacology & biological psychiatry · 2018 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCR3 | “In the present study, we investigated the production of Helios in CD4+, CD8+, and TIM-3+, CXCR3+ cells in typically developing (TD) controls and children with ASD and in peripheral blood mononuclear cells (PBMCs).” | 0.98 | hgnc_dict_v1 |
| phenotype | neurodevelopmental disorder | “Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder in which immunological imbalance has been suggested to be a major etiological component.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | autism spectrum disorder | “Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder in which immunological imbalance has been suggested to be a major etiological component.” | 0.98 | phenotype_alias_lexicon_v2 |
Resveratrol treatment attenuates chemokine receptor expression in the BTBR T+tf/J mouse model of autism.
PMID 27693537 | DOI 10.1016/j.mcn.2016.09.004 · Molecular and cellular neurosciences · 2016 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCR3 | “We investigated the effect of resveratrol (20 and 40mg/kg) in the spleen and brain tissues of BTBR T+tf/J (BTBR) and C57BL/6J (B6) mice as well as on the C-C chemokine receptor (CCR) and C-X-C motif chemokine receptor (CXCR) (CCR3+, CCR5+, CCR7+ and CCR9+, CXCR3+ and CXCR5+) in cluster of differentiation 4-positive (CD4+) T cells in the spleen.” | 0.98 | hgnc_dict_v1 |
| phenotype | neurodevelopmental disorder | “Autism is a neurodevelopmental disorder categorized by qualitative impairments in social interaction, communication, and repetitive stereotypic behavior.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CCR3 | “We investigated the effect of resveratrol (20 and 40mg/kg) in the spleen and brain tissues of BTBR T+tf/J (BTBR) and C57BL/6J (B6) mice as well as on the C-C chemokine receptor (CCR) and C-X-C motif chemokine receptor (CXCR) (CCR3+, CCR5+, CCR7+ and CCR9+, CXCR3+ and CXCR5+) in cluster of differentiation 4-positive (CD4+) T cells in the spleen.” | 0.98 | hgnc_dict_v1 |
| gene | CCR5 | “We investigated the effect of resveratrol (20 and 40mg/kg) in the spleen and brain tissues of BTBR T+tf/J (BTBR) and C57BL/6J (B6) mice as well as on the C-C chemokine receptor (CCR) and C-X-C motif chemokine receptor (CXCR) (CCR3+, CCR5+, CCR7+ and CCR9+, CXCR3+ and CXCR5+) in cluster of differentiation 4-positive (CD4+) T cells in the spleen.” | 0.98 | hgnc_dict_v1 |