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CXCR3 and rheumatoid arthritis are reported together in 1 article.
Gene
CXCR3
- HGNC
- HGNC:4540
14articles
14mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Rheumatoid arthritis
212articles
212mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60CXCR3 antagonist NBI-74330 mitigates joint inflammation in Collagen-Induced arthritis model in DBA/1J mice.
PMID 37018975 | DOI 10.1016/j.intimp.2023.110099 · International immunopharmacology · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCR3 | “CXCR3 antagonist NBI-74330 mitigates joint inflammation in Collagen-Induced arthritis model in DBA/1J mice.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by uncontrolled synovial proliferation, pannus formation, cartilage injury, and bone destruction.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | STAT4 | “Furthermore, using flow cytometry, we investigated the effects of NBI-74330 on Th1 (IFN-γ, TNF-α, T-bet, STAT4, Notch-3, and RANKL), Th17 (IL-21, IL-17A, STAT3, and RORγt), and Th22 (IL-22) cells in splenic CD4+ and CXCR3+T-cells.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Furthermore, using flow cytometry, we investigated the effects of NBI-74330 on Th1 (IFN-γ, TNF-α, T-bet, STAT4, Notch-3, and RANKL), Th17 (IL-21, IL-17A, STAT3, and RORγt), and Th22 (IL-22) cells in splenic CD4+ and CXCR3+T-cells.” | 0.98 | hgnc_dict_v1 |