Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Exploring the landscape of autoimmune disorder-associated genes and their impact on immune microenvironment in breast cancer patients.”	0.98	phenotype_alias_lexicon_v2
gene	MMP9	“Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.”	0.98	hgnc_dict_v1
gene	CTLA4	“Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.”	0.98	hgnc_dict_v1

PMID 41348904 | PMCID PMC12680324 | DOI 10.1371/journal.pone.0323665 · PloS one · 2025 · 6 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies.”	0.98	phenotype_alias_lexicon_v2
gene	IL19	“TGFβ-1, IL19, CXCR4, BMP1, VCAN, and WNT2 have been implicated to be instrumental to critical oncogenic pathways; however, their cumulative contribution toward the pathophysiology of BC has not yet been investigated.”	0.98	hgnc_dict_v1
gene	BMP1	“TGFβ-1, IL19, CXCR4, BMP1, VCAN, and WNT2 have been implicated to be instrumental to critical oncogenic pathways; however, their cumulative contribution toward the pathophysiology of BC has not yet been investigated.”	0.98	hgnc_dict_v1

PMID 37290620 | DOI 10.1016/j.envres.2023.116335 · Environmental research · 2023 · 3 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.”	0.98	phenotype_alias_lexicon_v2
gene	CXCL12	“CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.”	0.98	hgnc_dict_v1

PMID 34535679 | PMCID PMC8448841 | DOI 10.1038/s41523-021-00334-5 · NPJ breast cancer · 2021 · 3 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“In post-NAT residual tumors, RR cases showed high expression of SOX2 and CXCR4.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Recurrence biomarkers of triple negative breast cancer treated with neoadjuvant chemotherapy and anti-EGFR antibodies.”	0.98	phenotype_alias_lexicon_v2
gene	SOX2	“In post-NAT residual tumors, RR cases showed high expression of SOX2 and CXCR4.”	0.98	hgnc_dict_v1

PMID 31370904 | PMCID PMC6676640 | DOI 10.1186/s13058-019-1166-4 · Breast cancer research : BCR · 2019 · 7 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“Among these genes, the chemokine receptor CXCR4 plays a central role.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“The prognostic value of JUNB-positive CTCs in metastatic breast cancer: from bioinformatics to phenotypic characterization.”	0.98	phenotype_alias_lexicon_v2
gene	JUNB	“After prioritization according to the CXCR4 corresponding pathways, five molecules (JUNB, YWHAB, TYROBP, NFYA, and PRDX1) were selected for further analysis in biological samples.”	0.98	hgnc_dict_v1
gene	YWHAB	“After prioritization according to the CXCR4 corresponding pathways, five molecules (JUNB, YWHAB, TYROBP, NFYA, and PRDX1) were selected for further analysis in biological samples.”	0.98	hgnc_dict_v1

PMID 30564115 | PMCID PMC6288203 | DOI 10.3389/fphar.2018.01294 · Frontiers in pharmacology · 2018 · 2 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis.”	0.98	phenotype_alias_lexicon_v2

PMID 24692066 | PMCID PMC4146410 | DOI 10.1093/carcin/bgu080 · Carcinogenesis · 2014 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“Posttranscriptional control of the chemokine receptor CXCR4 expression in cancer cells.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“In the invasive breast cancer phenotype, aberrant expression of CXCR4 is linked to both TTP deficiency and HuR overexpression.”	0.98	phenotype_alias_lexicon_v2
gene	ZFP36	“Here, we find that CXCR4 harbors AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR) that bind and respond to the RNA-binding proteins, tristetraprolin (TTP/ZFP36) and HuR (ELAVL1).”	0.98	hgnc_dict_v1
gene	ELAVL1	“Here, we find that CXCR4 harbors AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR) that bind and respond to the RNA-binding proteins, tristetraprolin (TTP/ZFP36) and HuR (ELAVL1).”	0.98	hgnc_dict_v1