Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“In cancer, xanthohumol demonstrates remarkable efficacy by inhibiting tumor growth, angiogenesis, and metastasis through the suppression of critical pathways like CXCR4 and STAT3.”	0.98	hgnc_dict_v1
phenotype	diabetes mellitus	“It improves glucose homeostasis, lipid metabolism, and gut microbiota composition, offering therapeutic benefits for metabolic syndrome and diabetes.”	0.93	phenotype_alias_lexicon_v2
gene	STAT3	“This review highlights xanthohumol's ability to modulate key signaling pathways, including NF-κB, STAT3, and Nrf2, which are central to inflammation, oxidative stress, and cancer progression.”	0.98	hgnc_dict_v1
phenotype	inflammatory bowel disease	“As a flavonoid, xanthohumol exhibits potent antioxidant and anti-inflammatory properties, making it effective in alleviating inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and inflammatory bowel disease.”	0.98	phenotype_alias_lexicon_v2

PMID 29724198 | PMCID PMC5934787 | DOI 10.1186/s12933-018-0709-9 · Cardiovascular diabetology · 2018 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“MNCs cytometry showed higher percentage of CXCR4 double positivity for both CD34 and CD31 positive cells, indicating a functional improvement.”	0.98	hgnc_dict_v1
phenotype	diabetes mellitus	“The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial.”	0.93	phenotype_alias_lexicon_v2
gene	CD34	“The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial.”	0.98	hgnc_dict_v1
gene	SOD1	“Gene expression analysis showed an upregulation in CD34+ cells for antioxidant SOD1 (p < 0.05) and a downregulation in CD34- cells for IL-6 (p < 0.01).”	0.98	hgnc_dict_v1

PMID 25495026 | DOI 10.3109/02713683.2014.982829 · Current eye research · 2015 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“RESULTS: Diabetes and intravitreal injection of HMGB1 in normal rats induced significant upregulation of the mRNA levels of the chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) receptor CXCR4 and protein levels of hypoxia-inducible factor-1α, early growth response-1, tyrosine kinase 2 and the CXCL12/CXCR4 chemokine axis.”	0.98	hgnc_dict_v1
phenotype	diabetes mellitus	“RESULTS: Diabetes and intravitreal injection of HMGB1 in normal rats induced significant upregulation of the mRNA levels of the chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) receptor CXCR4 and protein levels of hypoxia-inducible factor-1α, early growth response-1, tyrosine kinase 2 and the CXCL12/CXCR4 chemokine axis.”	0.93	phenotype_alias_lexicon_v2
gene	HMGB1	“PURPOSE: The expression of high-mobility group box-1 (HMGB1) is upregulated in epiretinal membranes and vitreous fluid from patients with proliferative diabetic retinopathy and in the diabetic retina.”	0.98	hgnc_dict_v1
gene	CXCL12	“RESULTS: Diabetes and intravitreal injection of HMGB1 in normal rats induced significant upregulation of the mRNA levels of the chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) receptor CXCR4 and protein levels of hypoxia-inducible factor-1α, early growth response-1, tyrosine kinase 2 and the CXCL12/CXCR4 chemokine axis.”	0.98	hgnc_dict_v1

PMID 23262028 | PMCID PMC3767396 | DOI 10.1016/j.bone.2012.12.006 · Bone · 2013 · 12 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“Diabetes significantly upregulated mRNA levels of several chemokines in vivo including CCL4, CCL8, CCL6, CCL11, CCL20, CCL24, CXCL2, CXCL5 and chemokine receptors CCR5 and CXCR4.”	0.98	hgnc_dict_v1
phenotype	diabetes mellitus	“We investigated the impact of diabetes on chemokine expression in normal and diabetic fracture healing.”	0.93	phenotype_alias_lexicon_v2
gene	CCL4	“CCL4 were examined in fracture calluses by immunohistochemistry and the role of TNF in diabetes-enhanced expression was investigated by treatment of animals with the TNF-specific inhibitor, pegsunercept.”	0.98	hgnc_dict_v1
gene	TNF	“CCL4 were examined in fracture calluses by immunohistochemistry and the role of TNF in diabetes-enhanced expression was investigated by treatment of animals with the TNF-specific inhibitor, pegsunercept.”	0.98	hgnc_dict_v1

PMID 22070978 | PMCID PMC3233520 | DOI 10.1186/1476-511X-10-203 · Lipids in health and disease · 2011 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	CXCR4	“RESULTS: Flow cytometric analysis of the surface expressions of CXCR4 (CXCL12 receptor) and CCR7 (CCL21 receptor) on B and T cells revealed that the surface expressions of CXCR4 and CCR7 were not significantly altered in diabetic and WP-supplemented diabetic mice compared with control mice.”	0.98	hgnc_dict_v1
phenotype	diabetes mellitus	“BACKGROUND: Long and persistent uncontrolled diabetes tends to degenerate the immune system and leads to an increased incidence of infection.”	0.93	phenotype_alias_lexicon_v2
gene	CXCL12	“In this study, the effects of camel WP on the chemotaxis of B and T cells to CXCL12 and CCL21 in diabetic mice were investigated.”	0.98	hgnc_dict_v1
gene	CCL21	“In this study, the effects of camel WP on the chemotaxis of B and T cells to CXCL12 and CCL21 in diabetic mice were investigated.”	0.98	hgnc_dict_v1