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CXCR4 and lung cancer are reported together in 2 articles.
Gene
CXCR4
- HGNC
- HGNC:2561
39articles
39mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Lung cancer
398articles
398mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Potential Role of Tumor-derived MIF in B-Cell Antigen Presentation in Lung Adenocarcinoma: Single-cell and TCGA Analyses.
PMID 41318120 | DOI 10.21873/anticanres.17874 · Anticancer research · 2025 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCR4 | “RESULTS: Malignant cells showed the highest expression of MIF, which may interact with CD74 + CXCR4 + and CD74 + CD44 + receptor complexes on B cells, T cells, and myeloid cells, consistent with known MIF-mediated signaling pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “BACKGROUND/AIM: Lung adenocarcinoma (LUAD), a predominant subtype of non-small cell lung cancer (NSCLC), is characterized by a complex tumor microenvironment (TME) that drives immune evasion and contributes to variable clinical outcomes.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD74 | “RESULTS: Malignant cells showed the highest expression of MIF, which may interact with CD74 + CXCR4 + and CD74 + CD44 + receptor complexes on B cells, T cells, and myeloid cells, consistent with known MIF-mediated signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “RESULTS: Malignant cells showed the highest expression of MIF, which may interact with CD74 + CXCR4 + and CD74 + CD44 + receptor complexes on B cells, T cells, and myeloid cells, consistent with known MIF-mediated signaling pathways.” | 0.98 | hgnc_dict_v1 |
Phenotypic Characterization of Circulating Tumor Cells Isolated from Non-Small and Small Cell Lung Cancer Patients.
PMID 36612166 | PMCID PMC9818148 | DOI 10.3390/cancers15010171 · Cancers · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CXCR4 | “In the present study, we evaluated the expression of JUNB and CXCR4 in circulating tumor cells (CTCs) of lung cancer patients and investigated whether these proteins have prognostic clinical relevance.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “Phenotypic Characterization of Circulating Tumor Cells Isolated from Non-Small and Small Cell Lung Cancer Patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | JUNB | “In the present study, we evaluated the expression of JUNB and CXCR4 in circulating tumor cells (CTCs) of lung cancer patients and investigated whether these proteins have prognostic clinical relevance.” | 0.98 | hgnc_dict_v1 |