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CYP1B1 and breast cancer are reported together in 5 articles.
Gene
CYP1B1
- HGNC
- HGNC:2597
58articles
58mentions
8variants with confirmed gene link
Most co-reported phenotypes (articles)
primary congenital glaucoma 30breast cancer 5diabetes mellitus 3hypertension 2arrhythmia 1autism spectrum disorder 1colorectal cancer 1coronary artery disease 1
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
5 records shown · first 60Integrated Network Pharmacology, Molecular Modeling, LC-MS Profiling, and Semisynthetic Approach for the Roots of Rubia tinctorum L. Metabolites in Cancer Treatment.
PMID 40224436 | PMCID PMC11983213 | DOI 10.1021/acsomega.4c09853 · ACS omega · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP1B1 | “The most enriched cancer-linked target genes were PLCG1, BCL2, CYP1B1, NSD2, and ESR2.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Among the tested R. tinctorum extracts, the chloroform extract was the strongest one with an IC50 = 3.987 μg/mL on the MCF-7 breast cancer cell line.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PLCG1 | “The most enriched cancer-linked target genes were PLCG1, BCL2, CYP1B1, NSD2, and ESR2.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “The most enriched cancer-linked target genes were PLCG1, BCL2, CYP1B1, NSD2, and ESR2.” | 0.98 | hgnc_dict_v1 |
In vivo and in vitro studies evaluating the chemopreventive effect of metformin on the aryl hydrocarbon receptor-mediated breast carcinogenesis.
PMID 34867043 | PMCID PMC8626299 | DOI 10.1016/j.sjbs.2021.08.051 · Saudi journal of biological sciences · 2021 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP1B1 | “This effect was associated with activation of AhR and its downstream target genes; cytochrome P4501A1 (CYP1A1) and CYP1B1.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Mechanistically using in vitro human breast cancer MCF-7 cells, MET inhibited breast cancer stem cells spheroids formation and development by DMBA, which was accompanied by a proportional inhibition in CYP1A1 gene expression.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CYP1A1 | “This effect was associated with activation of AhR and its downstream target genes; cytochrome P4501A1 (CYP1A1) and CYP1B1.” | 0.98 | hgnc_dict_v1 |
Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms.
PMID 31058255 | PMCID PMC6452588 | DOI 10.1177/2516865719839011 · Epigenetics insights · 2019 · 19 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP1B1 | “Interestingly, several TSGs, such as DLC1, PPARG, ST7, FOXO6, TET2, CYP1B1, SALL4, and DDIT3, known to be epigenetically silenced in various tumors, including acute leukemia, were upregulated, along with the upregulation of several downstream pro-apoptotic genes, such as RASL11B, RASD1, GNG3, BAD, and BIK.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Data obtained from RNA sequencing were confirmed using quantitative reverse transcription polymerase chain reaction (RT-qPCR) in Jurkat cells, as well as in a human breast cancer cell line (MDA-MB-468 cells).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | UHRF1 | “We found that many key epigenetic players, including ubiquitin-like containing plant homeodomain (PHD) and really interesting new gene (RING) finger domains 1 (UHRF1), DNMT1,3A,3B, G9A, HDAC1,4,9, KDM1B, and KMT2A,B,C,D,E, were downregulated in TQ-treated Jurkat cells.” | 0.98 | hgnc_dict_v1 |
| gene | DNMT1 | “We found that many key epigenetic players, including ubiquitin-like containing plant homeodomain (PHD) and really interesting new gene (RING) finger domains 1 (UHRF1), DNMT1,3A,3B, G9A, HDAC1,4,9, KDM1B, and KMT2A,B,C,D,E, were downregulated in TQ-treated Jurkat cells.” | 0.98 | hgnc_dict_v1 |
Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population.
PMID 31477036 | PMCID PMC6720417 | DOI 10.1186/s12881-019-0884-x · BMC medical genetics · 2019 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP1B1 | “Therefore, this study aims to determine if there is any single nucleotide polymorphism (SNP) within CYP19A1, CYP2C19, CYP2C9, CYP1B1, CYP3A4, and CYP1A2 genes associated with BC in the Jordanian population.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CYP19A1 | “Therefore, this study aims to determine if there is any single nucleotide polymorphism (SNP) within CYP19A1, CYP2C19, CYP2C9, CYP1B1, CYP3A4, and CYP1A2 genes associated with BC in the Jordanian population.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Therefore, this study aims to determine if there is any single nucleotide polymorphism (SNP) within CYP19A1, CYP2C19, CYP2C9, CYP1B1, CYP3A4, and CYP1A2 genes associated with BC in the Jordanian population.” | 0.98 | hgnc_dict_v1 |
Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation.
PMID 28103884 | PMCID PMC5244521 | DOI 10.1186/s12943-016-0570-y · Molecular cancer · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP1B1 | “RESULTS: The constitutive mRNA expression and cellular content of CYP1A1 and CYP1B1, AhR-regulated genes, were markedly higher in CSCs more than differentiating non-CSCs of five different human breast cancer cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTEN | “Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “At the in vivo level, female Balb/c mice were treated with AhR/CYP1A1 inducer and histopathology changes and Immunohistochemistry examination for target proteins were determined.” | 0.98 | hgnc_dict_v1 |