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CYP1B1 and diabetes mellitus are reported together in 3 articles.
Gene
CYP1B1
- HGNC
- HGNC:2597
58articles
58mentions
8variants with confirmed gene link
Most co-reported phenotypes (articles)
primary congenital glaucoma 30breast cancer 5diabetes mellitus 3hypertension 2arrhythmia 1autism spectrum disorder 1colorectal cancer 1coronary artery disease 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes.
PMID 34367469 | PMCID PMC8337112 | DOI 10.1155/2021/9711176 · Oxidative medicine and cellular longevity · 2021 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP1B1 | “Of the top 15 proteins found by Cytoscape 3.6.1, 8, CAT and OGG1 (downregulated) and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 (upregulated), were dysregulated in diabetes-related kidney disease.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “The purpose of this study was to look into the effects of green coconut mesocarp juice extract (CMJE) on diabetes-related problems in streptozotocin- (STZ-) induced type 2 diabetes, as well as the antioxidative functions of its natural compounds in regulating the associated genes and biochemical markers.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | OGG1 | “Of the top 15 proteins found by Cytoscape 3.6.1, 8, CAT and OGG1 (downregulated) and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 (upregulated), were dysregulated in diabetes-related kidney disease.” | 0.98 | hgnc_dict_v1 |
| gene | CASP3 | “Of the top 15 proteins found by Cytoscape 3.6.1, 8, CAT and OGG1 (downregulated) and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 (upregulated), were dysregulated in diabetes-related kidney disease.” | 0.98 | hgnc_dict_v1 |
Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health.
PMID 30342560 | PMCID PMC6196025 | DOI 10.1186/s13148-018-0558-0 · Clinical epigenetics · 2018 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP1B1 | “RESULTS: We identified 42 smoking-methylation and 42 smoking-expression signals, where five genes (AHRR, CYP1A1, CYP1B1, CYTL1, F2RL3) were both hypo-methylated and upregulated in current smokers.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “BACKGROUND: Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | AHRR | “RESULTS: We identified 42 smoking-methylation and 42 smoking-expression signals, where five genes (AHRR, CYP1A1, CYP1B1, CYTL1, F2RL3) were both hypo-methylated and upregulated in current smokers.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “RESULTS: We identified 42 smoking-methylation and 42 smoking-expression signals, where five genes (AHRR, CYP1A1, CYP1B1, CYTL1, F2RL3) were both hypo-methylated and upregulated in current smokers.” | 0.98 | hgnc_dict_v1 |
Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and Atherosclerosis.
PMID 30139042 | PMCID PMC6171375 | DOI 10.22034/APJCP.2018.19.8.2057 · Asian Pacific journal of cancer prevention : APJCP · 2018 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP1B1 | “In this review, we discuss some of the most clinically important CYPs isoforms (CYP2D6, CYP2A6, CYP2C19, CYP2C9, CYP1B1 and CYP1A2) with respect to gene polymorphisms and drug metabolism.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and Atherosclerosis.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CYP2D6 | “In this review, we discuss some of the most clinically important CYPs isoforms (CYP2D6, CYP2A6, CYP2C19, CYP2C9, CYP1B1 and CYP1A2) with respect to gene polymorphisms and drug metabolism.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2A6 | “In this review, we discuss some of the most clinically important CYPs isoforms (CYP2D6, CYP2A6, CYP2C19, CYP2C9, CYP1B1 and CYP1A2) with respect to gene polymorphisms and drug metabolism.” | 0.98 | hgnc_dict_v1 |