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CYP3A4 and cystic fibrosis are reported together in 1 article.
Gene
CYP3A4
- HGNC
- HGNC:2637
49articles
49mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 4Crohn disease 3hepatocellular carcinoma 3stroke 3autism spectrum disorder 2breast cancer 2hepatitis B 2leukemia 2
Reported variants (articles · ClinVar status)
Phenotype
Cystic fibrosis
157articles
157mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Unveiling the heritability of selected unexplored pharmacogenetic markers in the Saudi population.
PMID 40376268 | PMCID PMC12078325 | DOI 10.3389/fphar.2025.1559399 · Frontiers in pharmacology · 2025 · 34 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP3A4 | “Three alleles were identified in CYP3A4, including a common (CYP3A4 rs2242480) and two rare alleles (*3 and *22).” | 0.98 | hgnc_dict_v1 |
| phenotype | cystic fibrosis | “The findings have implications for personalizing treatments for various conditions, including rheumatoid arthritis, cystic fibrosis, and hepatitis C.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | DPYD | “The selected variants in six genes [DPYD (rs1801268), CACNA1S (rs772226819), EGFR (rs121434568), RYR1 (rs193922816), CYP2B6 (rs3826711), and MT-RNR1 (rs267606617, rs267606618, rs267606619)] were found to be non-existing among Saudis.” | 0.98 | hgnc_dict_v1 |
| gene | CACNA1S | “The selected variants in six genes [DPYD (rs1801268), CACNA1S (rs772226819), EGFR (rs121434568), RYR1 (rs193922816), CYP2B6 (rs3826711), and MT-RNR1 (rs267606617, rs267606618, rs267606619)] were found to be non-existing among Saudis.” | 0.98 | hgnc_dict_v1 |