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CYP3A4 and diabetes mellitus are reported together in 4 articles.
Gene
CYP3A4
- HGNC
- HGNC:2637
49articles
49mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 4Crohn disease 3hepatocellular carcinoma 3stroke 3autism spectrum disorder 2breast cancer 2hepatitis B 2leukemia 2
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Genome-Wide Study of Diabetes Mellitus (Type 2)-Associated Genes in Homo sapiens (Human).
PMID 40462586 | DOI 10.1002/jgm.70025 · The journal of gene medicine · 2025 · 16 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP3A4 | “A chromosomal localization analysis showed that diabetes-associated genes were randomly positioned on human chromosomes, with four genes (ELMO1, GCK, GNAI, and CYP3A4) on Chr7, while seven individual genes included PPM1K, TDO2, GALNT7, PIK3R1, VEGFA, PTGS1, TCF7L2, GNG3, SIRT4, and SSTR2 on chromosome numbers 5, 6, 9, 10, 11, 12, and 17, respectively.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Genome-Wide Study of Diabetes Mellitus (Type 2)-Associated Genes in Homo sapiens (Human).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | FOS | “RESULTS: The findings revealed that the FOS gene was highly acidic with an isoelectric point (pI = 4.77); however, the VEGFA gene was greatly basic with an isoelectric point (pI = 9.24) as compared to the chosen genes in H. sapiens.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “RESULTS: The findings revealed that the FOS gene was highly acidic with an isoelectric point (pI = 4.77); however, the VEGFA gene was greatly basic with an isoelectric point (pI = 9.24) as compared to the chosen genes in H. sapiens.” | 0.98 | hgnc_dict_v1 |
Probing PXR activation and modulation of CYP3A4 by Tinospora crispa and Tinospora sinensis.
PMID 35245632 | PMCID PMC11094663 | DOI 10.1016/j.jep.2022.115159 · Journal of ethnopharmacology · 2022 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP3A4 | “Probing PXR activation and modulation of CYP3A4 by Tinospora crispa and Tinospora sinensis.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “ETHNOPHARMACOLOGICAL RELEVANCE: The two Tinospora species, T. crispa and T. sinensis, native to Southeast Asia, are integral components of various traditional preparations with structure-function claims to treat various disorders, including diabetes and inflammation.” | 0.93 | phenotype_alias_lexicon_v2 |
Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment.
PMID 33931001 | DOI 10.1080/17425255.2021.1925249 · Expert opinion on drug metabolism & toxicology · 2021 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP3A4 | “It is commonly used to reduce the risk of blood coagulation in patients diagnosed with acute coronary syndrome, or ischemic stroke.Area covered: We reviewed published articles in PubMed and Google Scholar that focused on the mutations of CYP2C19, CYP3A4, CYP2C9, CYP2B6, and CYP1A2 genes related to clopidogrel clinical efficacy and safety.Expert opinion: Based on current pharmacogenetic studies, patients carrying CYP2C19*2, CYP2C19*3, CYP2C9*3, and CYP2B6*5 alleles may not respond to clopidogrel due to poor platelet inhibition efficacy revealed among them.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Genotyping for either CYP2C19, CYP3A4, CYP2C9, CYP2B6, or CYP1A2 variants is not recommended when considering clopidogrel treatment for patients, as some trials showed specific non-genetic factors (e.g. age and diabetes) that could affect clopidogrel responsiveness.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CYP2C19 | “It is commonly used to reduce the risk of blood coagulation in patients diagnosed with acute coronary syndrome, or ischemic stroke.Area covered: We reviewed published articles in PubMed and Google Scholar that focused on the mutations of CYP2C19, CYP3A4, CYP2C9, CYP2B6, and CYP1A2 genes related to clopidogrel clinical efficacy and safety.Expert opinion: Based on current pharmacogenetic studies, patients carrying CYP2C19*2, CYP2C19*3, CYP2C9*3, and CYP2B6*5 alleles may not respond to clopidogrel due to poor platelet inhibition efficacy revealed among them.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C9 | “It is commonly used to reduce the risk of blood coagulation in patients diagnosed with acute coronary syndrome, or ischemic stroke.Area covered: We reviewed published articles in PubMed and Google Scholar that focused on the mutations of CYP2C19, CYP3A4, CYP2C9, CYP2B6, and CYP1A2 genes related to clopidogrel clinical efficacy and safety.Expert opinion: Based on current pharmacogenetic studies, patients carrying CYP2C19*2, CYP2C19*3, CYP2C9*3, and CYP2B6*5 alleles may not respond to clopidogrel due to poor platelet inhibition efficacy revealed among them.” | 0.98 | hgnc_dict_v1 |
Oncoglabrinol C, a new flavan from Oncocalyx glabratus protects endothelial cells against oxidative stress and apoptosis, and modulates hepatic CYP3A4 activity.
PMID 32550794 | PMCID PMC7292873 | DOI 10.1016/j.jsps.2020.04.004 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP3A4 | “Oncoglabrinol C, a new flavan from Oncocalyx glabratus protects endothelial cells against oxidative stress and apoptosis, and modulates hepatic CYP3A4 activity.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “This warrants further evaluations of Oncoglabrinol C and related compounds towards developing effective and safe drugs against diabetes associated cardiovascular disorders.” | 0.93 | phenotype_alias_lexicon_v2 |