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CYP3A4 and hepatitis B are reported together in 2 articles.
Gene
CYP3A4
- HGNC
- HGNC:2637
49articles
49mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 4Crohn disease 3hepatocellular carcinoma 3stroke 3autism spectrum disorder 2breast cancer 2hepatitis B 2leukemia 2
Reported variants (articles · ClinVar status)
Phenotype
Hepatitis B
255articles
255mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60The in vitro and in vivo anti-hepatotoxic, anti-hepatitis B virus and hepatic CYP450 modulating potential of Cyperus rotundus.
PMID 31061625 | PMCID PMC6488921 | DOI 10.1016/j.jsps.2019.02.003 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP3A4 | “In the present study we investigated the hepatotoprotective, hepatitis B virus (HBV) inhibitory and hepatic CYP450 enzyme (CYP3A4) modulatory potential of Cyperus rotundus rhizome fractions.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis B | “In the present study we investigated the hepatotoprotective, hepatitis B virus (HBV) inhibitory and hepatic CYP450 enzyme (CYP3A4) modulatory potential of Cyperus rotundus rhizome fractions.” | 0.98 | phenotype_alias_lexicon_v2 |
The anti-hepatitis B virus therapeutic potential of anthraquinones derived from Aloe vera.
PMID 31410907 | DOI 10.1002/ptr.6471 · Phytotherapy research : PTR · 2019 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP3A4 | “We therefore, tested the anti-HBV potential of AV extract and its anthraquinones in hepatoma cells, including molecular docking, high-performance thin layer chromatography (HPTLC), and cytochrome P450 (CYP3A4) activation analyses.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis B | “Although the approved hepatitis B virus (HBV)-polymerase inhibitors (e.g., lamivudine) often lead to drug-resistance, several natural products have shown promising efficacies.” | 0.98 | phenotype_alias_lexicon_v2 |