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CYP7A1 and obesity are reported together in 2 articles.
Gene
CYP7A1
- HGNC
- HGNC:2651
7articles
7mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Testosterone with Silymarin Improves Diabetes-obesity Comorbidity Complications by Modulating Inflammatory Responses and CYP7A1/ACC Gene Expressions in Rats.
PMID 37957854 | DOI 10.2174/0113862073272401231108054024 · Combinatorial chemistry & high throughput screening · 2024 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP7A1 | “Testosterone with Silymarin Improves Diabetes-obesity Comorbidity Complications by Modulating Inflammatory Responses and CYP7A1/ACC Gene Expressions in Rats.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “AIM: The goal of this study was to find out how well testosterone (TN) with silymarin (SN) protects against oxidative stress and inflammation in the liver of the experimental rats with type 2 diabetes (T2D) and obesity (DMOB).” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “AIM: The goal of this study was to find out how well testosterone (TN) with silymarin (SN) protects against oxidative stress and inflammation in the liver of the experimental rats with type 2 diabetes (T2D) and obesity (DMOB).” | 0.93 | phenotype_alias_lexicon_v2 |
Assessment of Two Potential Probiotic Strains As Anti-Obesity Supplements Under High-Fat Feeding Conditions.
PMID 35088380 | DOI 10.1007/s12602-022-09912-w · Probiotics and antimicrobial proteins · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP7A1 | “RT-PCR was used to determine the expression of CYP7A1, ALTG4, TNFα and ROR genes.The findings show that the obesity group recorded the significant highest value of the body weight, TC, TG, LDL, AST and ALT, while OLP group recorded the significant lowest value.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Obesity is one of the chronic diseases that increase annually and cause cardiovascular disease, which is the main cause of death worldwide.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TG | “RT-PCR was used to determine the expression of CYP7A1, ALTG4, TNFα and ROR genes.The findings show that the obesity group recorded the significant highest value of the body weight, TC, TG, LDL, AST and ALT, while OLP group recorded the significant lowest value.” | 0.98 | hgnc_dict_v1 |