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DPP4 and COVID-19 are reported together in 2 articles.
Gene
DPP4
- HGNC
- HGNC:3009
26articles
26mentions
4variants with confirmed gene link
Most co-reported phenotypes (articles)
MERS 14diabetes mellitus 4COVID-19 2SARS 2Alzheimer disease 1gastric cancer 1inflammatory bowel disease 1intellectual disability 1
Reported variants (articles · ClinVar status)
Phenotype
COVID-19
1,317articles
1,317mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Clinical Outcomes with the Use of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor Among Patients with Diabetes Mellitus and COVID-19: A Systematic Review of Observational Studies.
PMID 41899041 | PMCID PMC13026772 | DOI 10.3390/jcm15062117 · Journal of clinical medicine · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | DPP4 | “It has been suggested that the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pathway of entrance into the host cell might be assisted by dipeptidyl peptidase-4 (DPP4), leading to inflammation and cytokine storm, with replication into the airways and unfavorable effects in the lungs.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Clinical Outcomes with the Use of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor Among Patients with Diabetes Mellitus and COVID-19: A Systematic Review of Observational Studies.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “Clinical Outcomes with the Use of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor Among Patients with Diabetes Mellitus and COVID-19: A Systematic Review of Observational Studies.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | SARS | “It has been suggested that the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pathway of entrance into the host cell might be assisted by dipeptidyl peptidase-4 (DPP4), leading to inflammation and cytokine storm, with replication into the airways and unfavorable effects in the lungs.” | 0.93 | phenotype_alias_lexicon_v2 |
Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors.
PMID 38544813 | PMCID PMC10968008 | DOI 10.2147/JIR.S442106 · Journal of inflammation research · 2024 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | DPP4 | “DPP4 (Dipeptidyl-peptidase 4) a versatile protease, emerges as a prominent player in soluble and membrane-bound forms.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Its heightened expression has been intimately linked to the initiation and severity of diverse autoimmune diseases, spanning rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (SSc), inflammatory bowel disease, autoimmune diabetes, and even SARS-CoV-2 infection.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | ACE2 | “Elevated levels of angiotensin-converting enzyme 2 (ACE2) expression are associated with producing various coronavirus peptidases.” | 0.98 | hgnc_dict_v1 |
| phenotype | inflammatory bowel disease | “Its heightened expression has been intimately linked to the initiation and severity of diverse autoimmune diseases, spanning rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (SSc), inflammatory bowel disease, autoimmune diabetes, and even SARS-CoV-2 infection.” | 0.98 | phenotype_alias_lexicon_v2 |