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DPP4 and SARS are reported together in 2 articles.
Gene
DPP4
- HGNC
- HGNC:3009
26articles
26mentions
4variants with confirmed gene link
Most co-reported phenotypes (articles)
MERS 14diabetes mellitus 4COVID-19 2SARS 2Alzheimer disease 1gastric cancer 1inflammatory bowel disease 1intellectual disability 1
Reported variants (articles · ClinVar status)
Phenotype
SARS
347articles
347mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Clinical Outcomes with the Use of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor Among Patients with Diabetes Mellitus and COVID-19: A Systematic Review of Observational Studies.
PMID 41899041 | PMCID PMC13026772 | DOI 10.3390/jcm15062117 · Journal of clinical medicine · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | DPP4 | “It has been suggested that the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pathway of entrance into the host cell might be assisted by dipeptidyl peptidase-4 (DPP4), leading to inflammation and cytokine storm, with replication into the airways and unfavorable effects in the lungs.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “It has been suggested that the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pathway of entrance into the host cell might be assisted by dipeptidyl peptidase-4 (DPP4), leading to inflammation and cytokine storm, with replication into the airways and unfavorable effects in the lungs.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “Clinical Outcomes with the Use of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor Among Patients with Diabetes Mellitus and COVID-19: A Systematic Review of Observational Studies.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | COVID-19 | “Clinical Outcomes with the Use of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor Among Patients with Diabetes Mellitus and COVID-19: A Systematic Review of Observational Studies.” | 0.98 | phenotype_alias_lexicon_v2 |
A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective.
PMID 28855003 | PMCID PMC7079582 | DOI 10.1099/jmm.0.000565 · Journal of medical microbiology · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | DPP4 | “The Medline database was searched using combinations and variations of terms, including 'Middle East respiratory syndrome coronavirus', 'MERS-CoV', 'SARS', 'therapy', 'molecular', 'vaccine', 'prophylactic', 'S protein', 'DPP4', 'heptad repeat', 'protease', 'inhibitor', 'anti-viral', 'broad-spectrum', 'interferon', 'convalescent plasma', 'lopinavir ritonavir', 'antibodies', 'antiviral peptides' and 'live attenuated viruses'.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “The current therapies have mainly been adapted from severe acute respiratory syndrome (SARS-CoV) treatments, including broad-spectrum antibiotics, corticosteroids, interferons, ribavirin, lopinavir-ritonavir or mycophenolate mofetil, and have not been subject to well-organized clinical trials.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | TMPRSS2 | “These include viral S protein targeting; inhibitors of host proteases, including TMPRSS2, cathepsin L and furin protease, and of viral M(pro) and the PL(pro) proteases; convalescent plasma; and vaccine candidates.” | 0.98 | hgnc_dict_v1 |
| phenotype | MERS | “A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective.” | 0.93 | phenotype_alias_lexicon_v2 |