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DPP4 and ulcerative colitis are reported together in 1 article.
Gene
DPP4
- HGNC
- HGNC:3009
26articles
26mentions
4variants with confirmed gene link
Most co-reported phenotypes (articles)
MERS 14diabetes mellitus 4COVID-19 2SARS 2Alzheimer disease 1gastric cancer 1inflammatory bowel disease 1intellectual disability 1
Reported variants (articles · ClinVar status)
Phenotype
Ulcerative colitis
492articles
492mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Activation of AMPK/SIRT1/FOXO3a signaling by BMS-477118 (saxagliptin) mitigates chronic colitis in rats: uncovering new anti-inflammatory and antifibrotic roles.
PMID 39359253 | PMCID PMC11445602 | DOI 10.3389/fphar.2024.1456058 · Frontiers in pharmacology · 2024 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | DPP4 | “BMS-477118, a reversible inhibitor of dipeptidyl peptidase 4 (DPP4), has demonstrated anti-inflammatory properties in preclinical and clinical studies with minimal adverse effects compared to other antidiabetic agents.” | 0.98 | hgnc_dict_v1 |
| phenotype | ulcerative colitis | “Ulcerative colitis (UC) is a debilitating chronic disease marked by persistent inflammation and intestinal fibrosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SIRT1 | “Activation of AMPK/SIRT1/FOXO3a signaling by BMS-477118 (saxagliptin) mitigates chronic colitis in rats: uncovering new anti-inflammatory and antifibrotic roles.” | 0.98 | hgnc_dict_v1 |