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DRD2 and Alzheimer disease are reported together in 2 articles.
Gene
DRD2
- HGNC
- HGNC:3023
12articles
12mentions
5variants with confirmed gene link
Most co-reported phenotypes (articles)
Alzheimer disease 2Parkinson disease 2autism spectrum disorder 2breast cancer 1intellectual disability 1neurodevelopmental disorder 1obesity 1
Reported variants (articles · ClinVar status)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Neuroinflammation mediated repurposing of clemastine for Alzheimer's disease through network pharmacology, molecular dynamics, and experimental validation studies.
PMID 42307826 | DOI 10.1007/s10787-026-02293-4 · Inflammopharmacology · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | DRD2 | “Hub genes such as GSK3β, DRD1, DRD2, CHRNA4, and SLC6A4 were associated with neurotransmission and kinase signaling pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Neuroinflammation mediated repurposing of clemastine for Alzheimer's disease through network pharmacology, molecular dynamics, and experimental validation studies.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | NLRP3 | “Biochemical parameters including acetylcholinesterase (AChE) activity, oxidative stress markers (MDA, SOD, CAT, GSH), and inflammatory biomarkers (NLRP3, TNF-α, IL-1β) were evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | DRD1 | “Hub genes such as GSK3β, DRD1, DRD2, CHRNA4, and SLC6A4 were associated with neurotransmission and kinase signaling pathways.” | 0.98 | hgnc_dict_v1 |
The Protective and Therapeutic Anti-Alzheimer Potential of Olea europaea L. cv. Picual: An In Silico and In Vivo Study.
PMID 36557216 | PMCID PMC9784889 | DOI 10.3390/metabo12121178 · Metabolites · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | DRD2 | “Using pharmacology networking to specify the targets of the identified compounds with a relationship to Alzheimer's disease, it was possible to identify the VEGFA, AChE, and DRD2 genes as the top correlated genes to Alzheimer's disease with 8, 8, and 6 interactions in the same order.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Using pharmacology networking to specify the targets of the identified compounds with a relationship to Alzheimer's disease, it was possible to identify the VEGFA, AChE, and DRD2 genes as the top correlated genes to Alzheimer's disease with 8, 8, and 6 interactions in the same order.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | VEGFA | “Using pharmacology networking to specify the targets of the identified compounds with a relationship to Alzheimer's disease, it was possible to identify the VEGFA, AChE, and DRD2 genes as the top correlated genes to Alzheimer's disease with 8, 8, and 6 interactions in the same order.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “Picual (OEP) (Saudi Arabian olive cultivar, F.” | 0.95 | saudi_context_rules_v1 |