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DRD2 and autism spectrum disorder are reported together in 2 articles.
Gene
DRD2
- HGNC
- HGNC:3023
12articles
12mentions
5variants with confirmed gene link
Most co-reported phenotypes (articles)
Alzheimer disease 2Parkinson disease 2autism spectrum disorder 2breast cancer 1intellectual disability 1neurodevelopmental disorder 1obesity 1
Reported variants (articles · ClinVar status)
Phenotype
Autism spectrum disorder
- HPO
- HP:0000729
881articles
881mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Biomarker Variants of Dopamine Receptor Genes Influence the Binding Interaction Between Dopamine Receptor and Risperidone.
PMID 42052100 | PMCID PMC13117852 | DOI 10.2147/DDDT.S587705 · Drug design, development and therapy · 2026 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | DRD2 | “METHODS: Using state-of-the-art tools, the current study designed to predict the most deleterious SNPs of the five (DRD1, DRD2, DRD3, DRD4 and DRD5) dopamine receptors genes, and their impact on the function and structure of dopamine receptor protein and the binding with risperidone.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “INTRODUCTION: Risperidone is atypical antipsychotic medication commonly used to control behavioral symptoms in children with autism and widely considered a first-line treatment for acute and maintenance treatment of schizophrenia and bipolar mania.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | DRD1 | “METHODS: Using state-of-the-art tools, the current study designed to predict the most deleterious SNPs of the five (DRD1, DRD2, DRD3, DRD4 and DRD5) dopamine receptors genes, and their impact on the function and structure of dopamine receptor protein and the binding with risperidone.” | 0.98 | hgnc_dict_v1 |
| gene | DRD3 | “METHODS: Using state-of-the-art tools, the current study designed to predict the most deleterious SNPs of the five (DRD1, DRD2, DRD3, DRD4 and DRD5) dopamine receptors genes, and their impact on the function and structure of dopamine receptor protein and the binding with risperidone.” | 0.98 | hgnc_dict_v1 |
The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism.
PMID 38421437 | DOI 10.1007/s00228-024-03658-w · European journal of clinical pharmacology · 2024 · 18 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | DRD2 | “Genotype calls for 5 candidate PD receptor genes (DRD1, DRD2, DRD3, HTR2C, and HTR2A) were obtained and reported as wild type, heterozygous, or homozygous for 11 variants.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CYP3A4 | “The Axiom PharmacoFocus Array technique was employed to generate accurate star allele-predicted phenotypes of 3 PK genes (CYP3A4, CYP3A5, and CYP2D6).” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A5 | “The Axiom PharmacoFocus Array technique was employed to generate accurate star allele-predicted phenotypes of 3 PK genes (CYP3A4, CYP3A5, and CYP2D6).” | 0.98 | hgnc_dict_v1 |