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EGFR and diabetes mellitus are reported together in 4 articles.
Gene
EGFR
- HGNC
- HGNC:3236
290articles
290mentions
5variants with confirmed gene link
Most co-reported phenotypes (articles)
lung cancer 74breast cancer 57colorectal cancer 27lymphoma 6hepatocellular carcinoma 5diabetes mellitus 4leukemia 4gastric cancer 3
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Integrated in vitro, microarray, and network pharmacology analysis reveals the multi-target anti-diabetic potential of Vigna unguiculata.
PMID 40860754 | PMCID PMC12371541 | DOI 10.33393/dti.2025.3495 · Drug target insights · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | EGFR | “Protein-protein interaction (PPI) network analysis highlighted key genes like EGFR, PTGS2, and TLR4 as central nodes in diabetes-related pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “INTRODUCTION: Diabetes mellitus (DM), particularly type 2 DM (T2DM), is a chronic metabolic disorder requiring novel therapeutic approaches as the available therapies are not meeting the current challenges.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTGS2 | “Protein-protein interaction (PPI) network analysis highlighted key genes like EGFR, PTGS2, and TLR4 as central nodes in diabetes-related pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Protein-protein interaction (PPI) network analysis highlighted key genes like EGFR, PTGS2, and TLR4 as central nodes in diabetes-related pathways.” | 0.98 | hgnc_dict_v1 |
Endocrine manifestations of lung adenocarcinoma with epidermal growth factor receptor mutation mimicking tuberculosis: A case report and literature review.
PMID 40556846 | PMCID PMC12183751 | DOI 10.5339/qmj.2025.64 · Qatar medical journal · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | EGFR | “This case report discusses an unusual presentation of epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) initially mimicking tuberculosis (TB), complicated by pituitary involvement.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Further investigations revealed metastatic lung adenocarcinoma with pituitary metastasis, causing diabetes insipidus, hyperprolactinemia, adrenal insufficiency, and hypothyroidism.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | tuberculosis | “Endocrine manifestations of lung adenocarcinoma with epidermal growth factor receptor mutation mimicking tuberculosis: A case report and literature review.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | lung cancer | “BACKGROUND: Lung cancer is a leading cause of cancer-related mortality globally, often presenting with diverse and challenging manifestations.” | 0.98 | phenotype_alias_lexicon_v2 |
Forecasting the Pharmacological Mechanisms of Plumbago zeylanica and Solanum xanthocarpum in Diabetic Retinopathy Treatment: A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Study.
PMID 39336159 | PMCID PMC11429473 | DOI 10.3390/biology13090732 · Biology · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | EGFR | “Pathway enrichment was performed with Gene Ontology and KEGG databases; (3) Results: We identified 28 active phytoconstituents, targeting proteins such as EGFR, SRC, STAT3, AKT1, and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Forecasting the Pharmacological Mechanisms of Plumbago zeylanica and Solanum xanthocarpum in Diabetic Retinopathy Treatment: A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Study. (1) Background: Diabetic retinopathy (DR) is a major complication of diabetes, marked by abnormal angiogenesis, microaneurysms, and retinal hemorrhages.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | SRC | “Pathway enrichment was performed with Gene Ontology and KEGG databases; (3) Results: We identified 28 active phytoconstituents, targeting proteins such as EGFR, SRC, STAT3, AKT1, and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Pathway enrichment was performed with Gene Ontology and KEGG databases; (3) Results: We identified 28 active phytoconstituents, targeting proteins such as EGFR, SRC, STAT3, AKT1, and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study.
PMID 39590299 | PMCID PMC11592827 | DOI 10.3390/cimb46110705 · Current issues in molecular biology · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | EGFR | “Key targets like MMP9, EGFR, and AKT1 were highlighted, and the PPAR and PI3K-AKT signaling pathways were identified as the primary mechanisms through which CT may treat DN.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Cinnamomum tamala (CT), traditionally used in managing diabetes and kidney disorders, has shown potential in treating DN, although its active compounds and mechanisms are not fully understood.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | MMP9 | “Key targets like MMP9, EGFR, and AKT1 were highlighted, and the PPAR and PI3K-AKT signaling pathways were identified as the primary mechanisms through which CT may treat DN.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Key targets like MMP9, EGFR, and AKT1 were highlighted, and the PPAR and PI3K-AKT signaling pathways were identified as the primary mechanisms through which CT may treat DN.” | 0.98 | hgnc_dict_v1 |