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EIF2AK4 and hypertension are reported together in 2 articles.
Gene
EIF2AK4
- HGNC
- HGNC:19687
2articles
2mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Hypertension
828articles
828mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Genetic analysis and clinical phenotype of pulmonary arterial hypertension in an Algerian population.
PMID 42001268 | PMCID PMC13092106 | DOI 10.5144/0256-4947.2026.111 · Annals of Saudi medicine · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | EIF2AK4 | “RESULTS: Pathogenic variants were identified in 6 out of 30 patients (20%) involving BMPR2, SOX17, TBX4, ATP13A3, and EIF2AK4.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “Genetic analysis and clinical phenotype of pulmonary arterial hypertension in an Algerian population.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BMPR2 | “OBJECTIVES: To identify pathogenic variants in BMPR2 and other PAH-related genes in Algerian patients, enabling targeted screening of high-risk individuals, refined classification of variants of uncertain significance (VUS), and early, personalized clinical management.” | 0.98 | hgnc_dict_v1 |
| gene | SOX17 | “RESULTS: Pathogenic variants were identified in 6 out of 30 patients (20%) involving BMPR2, SOX17, TBX4, ATP13A3, and EIF2AK4.” | 0.98 | hgnc_dict_v1 |
A Challenging Case of Genetically and Histologically Diagnosed Pulmonary Veno-Occlusive Disease with Extracorporeal Life Support and Redo Lung Transplantation.
PMID 37649985 | PMCID PMC10465249 | DOI 10.1155/2023/4846338 · Case reports in cardiology · 2023 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | EIF2AK4 | “A genetic study was done and revealed the eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4) gene on chromosome 15, which was diagnostic to heritable PVOD.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “BACKGROUND: Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary arterial hypertension characterized by diffuse venous vasculopathy and increased pulmonary vascular resistance resulting in right-sided heart failure.” | 0.98 | phenotype_alias_lexicon_v2 |