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ESR1 and Alzheimer disease are reported together in 1 article.
Gene
ESR1
- HGNC
- HGNC:3467
52articles
52mentions
9variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 22lung cancer 4diabetes mellitus 2intellectual disability 2Alzheimer disease 1COVID-19 1Parkinson disease 1colorectal cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Multi-target therapeutic potential of Neem (Azadirachta indica) phytochemicals in Alzheimer's disease: an integrative network pharmacology and molecular dynamics simulation approach.
PMID 41113166 | PMCID PMC12534210 | DOI 10.1007/s40203-025-00434-1 · In silico pharmacology · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ESR1 | “Network analysis highlighted ESR1, HSP90AA1, SRC, HIF1A and EP300 as key hub genes within the AD-related compound-target network, suggesting critical regulatory roles.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Multi-target therapeutic potential of Neem (Azadirachta indica) phytochemicals in Alzheimer's disease: an integrative network pharmacology and molecular dynamics simulation approach.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HSP90AA1 | “Network analysis highlighted ESR1, HSP90AA1, SRC, HIF1A and EP300 as key hub genes within the AD-related compound-target network, suggesting critical regulatory roles.” | 0.98 | hgnc_dict_v1 |
| gene | SRC | “Network analysis highlighted ESR1, HSP90AA1, SRC, HIF1A and EP300 as key hub genes within the AD-related compound-target network, suggesting critical regulatory roles.” | 0.98 | hgnc_dict_v1 |