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ESR1 and Parkinson disease are reported together in 1 article.
Gene
ESR1
- HGNC
- HGNC:3467
52articles
52mentions
9variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 22lung cancer 4diabetes mellitus 2intellectual disability 2Alzheimer disease 1COVID-19 1Parkinson disease 1colorectal cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Parkinson disease
280articles
280mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Multi-Transcriptome-Informed Network Pharmacology Reveals Novel Biomarkers and Therapeutic Candidates for Parkinson's Disease.
PMID 41465132 | PMCID PMC12732698 | DOI 10.3390/genes16121459 · Genes · 2025 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ESR1 | “Then, protein-protein interaction (PPI) network analysis pinpointed seven top-ranked DEGs (GAPDH, PTEN, CCND1, APOE, ESR1, MAPK3/ERK1, and SNCA) as KGs or central modulators of PD pathogenesis.” | 0.98 | hgnc_dict_v1 |
| phenotype | Parkinson disease | “Multi-Transcriptome-Informed Network Pharmacology Reveals Novel Biomarkers and Therapeutic Candidates for Parkinson's Disease.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | GAPDH | “Then, protein-protein interaction (PPI) network analysis pinpointed seven top-ranked DEGs (GAPDH, PTEN, CCND1, APOE, ESR1, MAPK3/ERK1, and SNCA) as KGs or central modulators of PD pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Then, protein-protein interaction (PPI) network analysis pinpointed seven top-ranked DEGs (GAPDH, PTEN, CCND1, APOE, ESR1, MAPK3/ERK1, and SNCA) as KGs or central modulators of PD pathogenesis.” | 0.98 | hgnc_dict_v1 |