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ESR1 and diabetes mellitus are reported together in 2 articles.
Gene
ESR1
- HGNC
- HGNC:3467
52articles
52mentions
9variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 22lung cancer 4diabetes mellitus 2intellectual disability 2Alzheimer disease 1COVID-19 1Parkinson disease 1colorectal cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Comparative Efficacy of Metformin and Glimepiride in Modulating Pharmacological Network to Increase BDNF Levels and Benefit Type 2 Diabetes-Related Cognitive Impairment.
PMID 38001940 | PMCID PMC10669717 | DOI 10.3390/biomedicines11112939 · Biomedicines · 2023 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ESR1 | “Whereas, glimepiride increases BDNF by binding to KCNJ11 via AP2M1 and ESR1 proteins.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Cognitive impairment is anotable complication of type 2 diabetes (T2DM), accompanied by reduced brain-derived neurotrophic factor (BDNF) in the brain and blood.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | BDNF | “Comparative Efficacy of Metformin and Glimepiride in Modulating Pharmacological Network to Increase BDNF Levels and Benefit Type 2 Diabetes-Related Cognitive Impairment.” | 0.98 | hgnc_dict_v1 |
| gene | PRKAB1 | “Metformin stimulates BDNF via APP binding to the PRKAB1 receptor.” | 0.98 | hgnc_dict_v1 |
Biochemical Characterization and Molecular Determination of Estrogen Receptor-α (ESR1 PvuII-rs2234693 T>C) and MiRNA-146a (rs2910164 C>G) Polymorphic Gene Variations and Their Association with the Risk of Polycystic Ovary Syndrome.
PMID 35270805 | PMCID PMC8910123 | DOI 10.3390/ijerph19053114 · International journal of environmental research and public health · 2022 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ESR1 | “Biochemical Characterization and Molecular Determination of Estrogen Receptor-α (ESR1 PvuII-rs2234693 T>C) and MiRNA-146a (rs2910164 C>G) Polymorphic Gene Variations and Their Association with the Risk of Polycystic Ovary Syndrome.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “PCOS is a risk factor for diabetes mellitus, obstructive sleep apnea, obesity and depression in patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | obesity | “PCOS is a risk factor for diabetes mellitus, obstructive sleep apnea, obesity and depression in patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs2234693 | “Biochemical Characterization and Molecular Determination of Estrogen Receptor-α (ESR1 PvuII-rs2234693 T>C) and MiRNA-146a (rs2910164 C>G) Polymorphic Gene Variations and Their Association with the Risk of Polycystic Ovary Syndrome.” | 0.90 | hgvs_regex_v1 |