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ETS1 and hypertension are reported together in 1 article.
Gene
ETS1
- HGNC
- HGNC:3488
7articles
7mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Hypertension
828articles
828mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension.
PMID 32132543 | PMCID PMC7055281 | DOI 10.1038/s41467-020-14966-x · Nature communications · 2020 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ETS1 | “Here, we show that KLF2-induced exosomal microRNAs, miR-181a-5p and miR-324-5p act together to attenuate pulmonary vascular remodelling and that their actions are mediated by Notch4 and ETS1 and other key regulators of vascular homoeostasis.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | KLF2 | “Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH.” | 0.98 | hgnc_dict_v1 |
| variant | p.H288Y | “Expressions of KLF2, miR-181a-5p and miR-324-5p are reduced, while levels of their target genes are elevated in pre-clinical PAH, idiopathic PAH and heritable PAH with missense p.H288Y KLF2 mutation.” | 0.95 | hgvs_regex_v1 |