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FGFR3 and breast cancer are reported together in 1 article.
Gene
FGFR3
- HGNC
- HGNC:3690
24articles
24mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
skeletal dysplasia 4multiple myeloma 2COVID-19 1breast cancer 1congenital cataract 1developmental delay 1hearing loss 1primary congenital glaucoma 1
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Post-transcriptional screen of cancer amplified genes identifies ERBB2/Her2 signaling as AU-rich mRNA stability-promoting pathway.
PMID 34535639 | PMCID PMC8448767 | DOI 10.1038/s41389-021-00351-w · Oncogenesis · 2021 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FGFR3 | “Screening for the impact of other amplified cancer genes in HEK293 cells also demonstrated that EGFR, AKT2, CCND1, CCNE1, SKP2, and FGFR3 caused both increased abundance of phosphorylated ZFP36/TTP and ARE-post-transcriptional reporter activity.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “The ERBB1/2 inhibitor, lapatinib, led to the reversal of the aberrant ARE-mediated process in ERBB2-amplified breast cancer cells.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ERBB2 | “Post-transcriptional screen of cancer amplified genes identifies ERBB2/Her2 signaling as AU-rich mRNA stability-promoting pathway.” | 0.98 | hgnc_dict_v1 |
| gene | ZFP36 | “The ERBB2 inhibitor decreased both the abundance and stability of the phosphorylated inactive form of the mRNA decay-promoting protein, tristetraprolin (ZFP36/TTP).” | 0.98 | hgnc_dict_v1 |