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FLG and allergic rhinitis are reported together in 2 articles.
Gene
FLG
- HGNC
- HGNC:3748
12articles
12mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Allergic rhinitis
30articles
30mentions
5co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity.
PMID 40105091 | PMCID PMC11920881 | DOI 10.1002/iid3.70116 · Immunity, inflammation and disease · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FLG | “Asthma risk alleles for; rs61816764 (FLG) and rs9303277 (IKFZ3) were associated with childhood onset disease (p = 2.67 × 10- 4 and 2.20 × 10- 7; retrospectively).” | 0.98 | hgnc_dict_v1 |
| phenotype | allergic rhinitis | “Childhood-onset asthma was characterized by elevated total IgE, allergic rhinitis and dermatitis.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | asthma | “Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs61816764 | “Asthma risk alleles for; rs61816764 (FLG) and rs9303277 (IKFZ3) were associated with childhood onset disease (p = 2.67 × 10- 4 and 2.20 × 10- 7; retrospectively).” | 0.90 | hgvs_regex_v1 |
Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.
PMID 33538231 | DOI 10.1080/15257770.2021.1880009 · Nucleosides, nucleotides & nucleic acids · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FLG | “This research detected 227 variants in the filaggrin gene (FLG gene).” | 0.98 | hgnc_dict_v1 |
| phenotype | allergic rhinitis | “Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | asthma | “Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | atopic dermatitis | “Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.” | 0.98 | phenotype_alias_lexicon_v2 |