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FLG and atopic dermatitis are reported together in 4 articles.
Gene
FLG
- HGNC
- HGNC:3748
12articles
12mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Atopic dermatitis
132articles
132mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Polymorphisms of the filaggrin gene are associated with atopic dermatitis in the Caucasian population of Central Russia.
PMID 35092857 | DOI 10.1016/j.gene.2022.146219 · Gene · 2022 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FLG | “Association of the filaggrin (FLG) gene with atopic dermatitis (AD) in Caucasians from Central Russia was studied in the sample of 700 patients and 612 controls.” | 0.98 | hgnc_dict_v1 |
| phenotype | atopic dermatitis | “Polymorphisms of the filaggrin gene are associated with atopic dermatitis in the Caucasian population of Central Russia.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs61816761 | “In total ten SNPs of the gene (rs61816761, rs12130219, rs77199844, rs558269137, rs4363385, rs12144049, rs471144, rs6661961, rs10888499, rs3126085), their haplotypes and interlocus interactions were analyzed using logistic regression.” | 0.90 | hgvs_regex_v1 |
| variant | rs12130219 | “In total ten SNPs of the gene (rs61816761, rs12130219, rs77199844, rs558269137, rs4363385, rs12144049, rs471144, rs6661961, rs10888499, rs3126085), their haplotypes and interlocus interactions were analyzed using logistic regression.” | 0.90 | hgvs_regex_v1 |
Filaggrin gene polymorphisms are associated with atopic dermatitis in women but not in men in the Caucasian population of Central Russia.
PMID 34882715 | PMCID PMC8659355 | DOI 10.1371/journal.pone.0261026 · PloS one · 2021 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FLG | “BACKGROUND AND PURPOSE: This study aimed to analyze the gender-specific association of the filaggrin (FLG) gene polymorphisms with atopic dermatitis (AD) in Caucasians from the central region of Russia.” | 0.98 | hgnc_dict_v1 |
| phenotype | atopic dermatitis | “Filaggrin gene polymorphisms are associated with atopic dermatitis in women but not in men in the Caucasian population of Central Russia.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs12130219 | “RESULTS: Significant associations were identified between seven SNPs of the FLG gene (rs12130219, rs61816761, rs558269137, rs12144049, rs3126085, rs471144, rs6661961) and AD in females: rs12144049 was associated independent individually (for allele C OR = 1.71, 95%Сl 1.19-2.46, рperm = 0.004 and OR = 1.76, 95%Сl 1.18-2.63, рperm = 0.006 according to the additive and dominant genetic models, respectively) and seven SNPs of the FLG gene within 14 haplotypes.” | 0.90 | hgvs_regex_v1 |
| variant | rs61816761 | “RESULTS: Significant associations were identified between seven SNPs of the FLG gene (rs12130219, rs61816761, rs558269137, rs12144049, rs3126085, rs471144, rs6661961) and AD in females: rs12144049 was associated independent individually (for allele C OR = 1.71, 95%Сl 1.19-2.46, рperm = 0.004 and OR = 1.76, 95%Сl 1.18-2.63, рperm = 0.006 according to the additive and dominant genetic models, respectively) and seven SNPs of the FLG gene within 14 haplotypes.” | 0.90 | hgvs_regex_v1 |
Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.
PMID 33538231 | DOI 10.1080/15257770.2021.1880009 · Nucleosides, nucleotides & nucleic acids · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FLG | “This research detected 227 variants in the filaggrin gene (FLG gene).” | 0.98 | hgnc_dict_v1 |
| phenotype | atopic dermatitis | “Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | asthma | “Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | allergic rhinitis | “Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.” | 0.98 | phenotype_alias_lexicon_v2 |
Uncommon Filaggrin Variants Are Associated with Persistent Atopic Dermatitis in African Americans.
PMID 29428354 | PMCID PMC6272058 | DOI 10.1016/j.jid.2018.01.029 · The Journal of investigative dermatology · 2018 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FLG | “Atopic dermatitis (AD) is a common illness that has been associated with filaggrin gene (FLG) loss of function (LoF) variation.” | 0.98 | hgnc_dict_v1 |
| phenotype | atopic dermatitis | “Uncommon Filaggrin Variants Are Associated with Persistent Atopic Dermatitis in African Americans.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | p.R501X | “The most common variants were p.R501X (1.72%, 95% CI = 0.79-3.24), p.S3316X (1.34%, 95% CI = 0.54-2.73), and p.R826X (0.95%, 95% CI = 0.31-2.2).” | 0.95 | hgvs_regex_v1 |
| variant | p.S3316X | “The most common variants were p.R501X (1.72%, 95% CI = 0.79-3.24), p.S3316X (1.34%, 95% CI = 0.54-2.73), and p.R826X (0.95%, 95% CI = 0.31-2.2).” | 0.95 | hgvs_regex_v1 |