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FOXO1 and cardiomyopathy are reported together in 2 articles.
Gene
FOXO1
- HGNC
- HGNC:3819
32articles
32mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Cardiomyopathy
- HPO
- HP:0001638
618articles
618mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Kaempferol protects against streptozotocin-induced diabetic cardiomyopathy in rats by a hypoglycemic effect and upregulating SIRT1.
PMID 34810287 | DOI 10.26402/jpp.2021.3.04 · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FOXO1 | “These events were associated with increased deacetylase activity and total levels of SIRT1 and a parallel decrease in the acetylation of Nrf2, NF-κB, smad2, and FOXO1.” | 0.98 | hgnc_dict_v1 |
| phenotype | cardiomyopathy | “Kaempferol protects against streptozotocin-induced diabetic cardiomyopathy in rats by a hypoglycemic effect and upregulating SIRT1.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SIRT1 | “Kaempferol protects against streptozotocin-induced diabetic cardiomyopathy in rats by a hypoglycemic effect and upregulating SIRT1.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Adult male rats were divided into 5 groups (n = 12/each) as control, control + kaempferol, STZ-induced diabetes mellitus (STZ-DM), STZ-DM + kaempferol, and STZ-DM + kaempferol + EX-527, a sirtuin 1 (SIRT1) inhibitor.” | 0.98 | phenotype_alias_lexicon_v2 |
Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling.
PMID 33901999 | DOI 10.26402/jpp.2020.6.12 · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2020 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FOXO1 | “Of note, EA increased the expression and activity of SIRT1 and suppressed the acetylation of nuclear factor erythroid-derived 2-like 2 (Nrf2), nuclear factor kappa B (NF-κB), smad2, and forkhead box, class O (FOXO1) in the LVs of both the control and diabetic groups.” | 0.98 | hgnc_dict_v1 |
| phenotype | cardiomyopathy | “Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SIRT1 | “This study investigated the protective effect of ellagic acid (EA) against diabetic cardiomyopathy (DC) in streptozotocin (STZ)-treated rats and examined if the mechanism of protection involves modulating silent information regulator 1 (SIRT1).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Adult male rats were divided into 5 groups (n = 12/each) as control, control + EA, diabetes mellitus (DM), STZ + EA, and STZ + EA + EX-527 (a SIRT1 inhibitor).” | 0.98 | phenotype_alias_lexicon_v2 |