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FOXO3 and hepatocellular carcinoma are reported together in 1 article.
Gene
FOXO3
- HGNC
- HGNC:3821
15articles
15mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 2COVID-19 1MERS 1colorectal cancer 1diabetes mellitus 1hepatocellular carcinoma 1leukemia 1ovarian cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Hepatocellular carcinoma
417articles
417mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Nanoparticle-based approaches for doxorubicin delivery in hepatocellular carcinoma: Current strategies and emerging innovations.
PMID 41273988 | DOI 10.1016/j.seminoncol.2025.152434 · Seminars in oncology · 2026 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FOXO3 | “In this review, we examined current knowledge on the specific molecular mechanisms of doxorubicin resistance in HCC, including overexpression of drug efflux (ABC family) transporters, aberrations of the drug target topoisomerase IIα (TOP2A), impairments in apoptosis (p53, FOXO3, Bcl-2 family members), oncogenic activation of pro-survival signaling pathways (NF-κB, PI3K/Akt, and MAPKs), instances of tumor heterogeneity with sirtuins, and cancer stem cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Nanoparticle-based approaches for doxorubicin delivery in hepatocellular carcinoma: Current strategies and emerging innovations.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TOP2A | “In this review, we examined current knowledge on the specific molecular mechanisms of doxorubicin resistance in HCC, including overexpression of drug efflux (ABC family) transporters, aberrations of the drug target topoisomerase IIα (TOP2A), impairments in apoptosis (p53, FOXO3, Bcl-2 family members), oncogenic activation of pro-survival signaling pathways (NF-κB, PI3K/Akt, and MAPKs), instances of tumor heterogeneity with sirtuins, and cancer stem cells.” | 0.98 | hgnc_dict_v1 |