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FOXO3 and leukemia are reported together in 1 article.
Gene
FOXO3
- HGNC
- HGNC:3821
15articles
15mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 2COVID-19 1MERS 1colorectal cancer 1diabetes mellitus 1hepatocellular carcinoma 1leukemia 1ovarian cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Fe3O4-Coated CNTs-Gum Arabic Nano-Hybrid Composites Exhibit Enhanced Anti-Leukemia Potency Against AML Cells via ROS-Mediated Signaling.
PMID 39055376 | PMCID PMC11269411 | DOI 10.2147/IJN.S467733 · International journal of nanomedicine · 2024 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FOXO3 | “The nanostructures lead to an increase in the expression of genes encoding proteins related to oxidative stress (SIRT1, FOXO3, NFE2L2, and MAP3K5) and cyclin-dependent kinase inhibitors (CDKN1A and CDKN1B) in response to ROS.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Fe3O4-Coated CNTs-Gum Arabic Nano-Hybrid Composites Exhibit Enhanced Anti-Leukemia Potency Against AML Cells via ROS-Mediated Signaling.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CD34 | “METHODS: Hybrid NPs were synthesized, characterized, and assessed for their cytotoxicity against Kasumi-1, HL-60, and THP-1 in comparison to normal primary bone marrow CD34+ cells.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The nanostructures lead to an increase in the expression of genes encoding proteins related to oxidative stress (SIRT1, FOXO3, NFE2L2, and MAP3K5) and cyclin-dependent kinase inhibitors (CDKN1A and CDKN1B) in response to ROS.” | 0.98 | hgnc_dict_v1 |