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G6PD and diabetes mellitus are reported together in 5 articles.
Gene
G6PD
- HGNC
- HGNC:4057
107articles
107mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
glucose-6-phosphate dehydrogenase deficiency 78sickle cell disease 12thalassemia 9sickle cell anemia 8malaria 7diabetes mellitus 5COVID-19 3autism spectrum disorder 3
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
5 records shown · first 60Pregnancy-Triggered Vaso-Occlusive Crises in Hemoglobin SE Disease Complicated by Glucose-6-Phosphate Dehydrogenase Deficiency: A Case Report.
PMID 41742975 | PMCID PMC12931828 | DOI 10.7759/cureus.102265 · Cureus · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “Hemoglobin SE (HbSE) disease is a rare hemoglobinopathy that may be associated with significant clinical complications despite its traditional characterization as a mild condition, and concomitant glucose-6-phosphate dehydrogenase (G6PD) deficiency can further complicate diagnosis and management.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Six years later, during her fourth pregnancy complicated by gestational diabetes, she developed severe lower limb pain.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “Pregnancy-Triggered Vaso-Occlusive Crises in Hemoglobin SE Disease Complicated by Glucose-6-Phosphate Dehydrogenase Deficiency: A Case Report.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “We report the case of a 40-year-old Saudi woman with known G6PD deficiency who experienced recurrent vaso-occlusive crises triggered by pregnancy.” | 0.95 | saudi_context_rules_v1 |
Diabetic Ketoacidosis Revealing Severe Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD-D) Deficiency with Methemoglobinemia: A Case Report.
PMID 31113928 | PMCID PMC6543950 | DOI 10.12659/AJCR.915007 · The American journal of case reports · 2019 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “Although acute hemolytic crises are usually induced by the exposure to certain oxidative stresses, diabetic ketoacidosis may also elicit hemolytic reactions in G6PD deficient persons.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “CASE REPORT A 17-year-old male with type 1 diabetes mellitus presented with diabetic ketoacidosis and features of hemolytic anemia which turned to be G6PD-D related.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “Diabetic Ketoacidosis Revealing Severe Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD-D) Deficiency with Methemoglobinemia: A Case Report.” | 0.98 | phenotype_alias_lexicon_v2 |
Glucose-6-phosphate dehydrogenase deficiency induced haemolysis in a woman with newly diagnosed diabetes after normalisation of hyperglycaemia.
PMID 28523859 | DOI 10.1111/dme.13385 · Diabetic medicine : a journal of the British Diabetic Association · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “BACKGROUND: The association between diabetes and G6PD deficiency is still a matter of debate.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Glucose-6-phosphate dehydrogenase deficiency induced haemolysis in a woman with newly diagnosed diabetes after normalisation of hyperglycaemia.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “Glucose-6-phosphate dehydrogenase deficiency induced haemolysis in a woman with newly diagnosed diabetes after normalisation of hyperglycaemia.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “CASE REPORT: We reported a 19-year-old Saudi women newly diagnosed with Type 1 diabetes in whom hemolytic crises occurred soon after normalization of hyperglycemia and revealed a G6PD deficiency.” | 0.95 | saudi_context_rules_v1 |
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
PMID 28898252 | PMCID PMC5595282 | DOI 10.1371/journal.pmed.1002383 · PLoS medicine · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “Yet, in African Americans, the X-linked G6PD G202A variant (T-allele frequency 11%) was associated with an absolute decrease in HbA1c of 0.81%-units (95% CI 0.66-0.96) per allele in hemizygous men, and 0.68%-units (95% CI 0.38-0.97) in homozygous women.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “CONCLUSIONS: As G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common.” | 0.93 | phenotype_alias_lexicon_v2 |
| variant | G202A | “Yet, in African Americans, the X-linked G6PD G202A variant (T-allele frequency 11%) was associated with an absolute decrease in HbA1c of 0.81%-units (95% CI 0.66-0.96) per allele in hemizygous men, and 0.68%-units (95% CI 0.38-0.97) in homozygous women.” | 0.82 | literature_variant_regex_v2 |
Glucose-6-phosphate dehydrogenase deficiency and diabetes mellitus.
PMID 1777604 · International journal of hematology · 1991 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “This hospital-based study demonstrates a statistically significant higher prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among the Saudi patients with diabetes mellitus (12.4%) as compared to healthy population controls (2.0%) (p less than 0.008).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Glucose-6-phosphate dehydrogenase deficiency and diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “Glucose-6-phosphate dehydrogenase deficiency and diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “This hospital-based study demonstrates a statistically significant higher prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among the Saudi patients with diabetes mellitus (12.4%) as compared to healthy population controls (2.0%) (p less than 0.008).” | 0.95 | saudi_context_rules_v1 |