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G6PD and malaria are reported together in 7 articles.
Gene
G6PD
- HGNC
- HGNC:4057
107articles
107mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
glucose-6-phosphate dehydrogenase deficiency 78sickle cell disease 12thalassemia 9sickle cell anemia 8malaria 7diabetes mellitus 5COVID-19 3autism spectrum disorder 3
Reported variants (articles · ClinVar status)
Phenotype
Malaria
232articles
232mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
7 records shown · first 60Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines.
PMID 38308253 | PMCID PMC10835850 | DOI 10.1186/s12936-024-04864-8 · Malaria journal · 2024 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Hail | “Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines. METHODS: The prevalence of G6PD deficiency among 408 Thai participants diagnosed with malaria by microscopy (71), and malaria-negative controls (337), was assessed using a phenotypic test based on water-soluble tetrazolium salts.” | 0.80 | saudi_context_rules_v1 |
Joint quantile disease mapping with application to malaria and G6PD deficiency.
PMID 38179076 | PMCID PMC10762445 | DOI 10.1098/rsos.230851 · Royal Society open science · 2024 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “Joint quantile disease mapping with application to malaria and G6PD deficiency.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Joint quantile disease mapping with application to malaria and G6PD deficiency.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “Joint quantile disease mapping with application to malaria and G6PD deficiency.” | 0.93 | phenotype_alias_lexicon_v2 |
Antibody responses to P. falciparum Apical Membrane Antigen 1(AMA-1) in relation to haemoglobin S (HbS), HbC, G6PD and ABO blood groups among Fulani and Masaleit living in Western Sudan.
PMID 29486174 | DOI 10.1016/j.actatropica.2018.02.030 · Acta tropica · 2018 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “Antibody responses to P. falciparum Apical Membrane Antigen 1(AMA-1) in relation to haemoglobin S (HbS), HbC, G6PD and ABO blood groups among Fulani and Masaleit living in Western Sudan.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Fulani and Masaleit are two sympatric ethnic groups in western Sudan who are characterised by marked differences in susceptibility to Plasmodium falciparum malaria.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | sickle cell anemia | “The results indicate that the Fulani ethnic group show lower frequency of HbAS, HbSS and HbAC compared to the Masaleit ethnic group.” | 0.93 | phenotype_alias_lexicon_v2 |
G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map.
PMID 23152723 | PMCID PMC3496665 | DOI 10.1371/journal.pmed.1001339 · PLoS medicine · 2012 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map.” | 0.93 | phenotype_alias_lexicon_v2 |
Sickle cell disease in Bahrain: coexistence and interaction with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
PMID 9604591 | DOI 10.1093/tropej/44.2.70 · Journal of tropical pediatrics · 1998 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “Sickle cell disease in Bahrain: coexistence and interaction with glucose-6-phosphate dehydrogenase (G6PD) deficiency.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “We speculate that the observation could be explained on the basis of historic endemicity of Falciparum malaria in both regions on the East coast of the Saudi Peninsula.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | sickle cell disease | “Sickle cell disease in Bahrain: coexistence and interaction with glucose-6-phosphate dehydrogenase (G6PD) deficiency.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “G6PD deficiency (very low to undetectable) was identified in 59 samples (47 per cent) of the study group and 35 (19 per cent) of the control group.” | 0.93 | phenotype_alias_lexicon_v2 |
Glucose-6-phosphate dehydrogenase deficiency in Saudi Arabia. A study in Al-Ula.
PMID 3235096 | DOI 10.1159/000153805 · Human heredity · 1988 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “This paper reports the frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the male and female population of A1-Ula in the northwestern province of Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “This frequency is significantly lower than those reported for other malaria endemic regions in Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “Glucose-6-phosphate dehydrogenase deficiency in Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Western Province | “Glucose-6-phosphate dehydrogenase deficiency in Saudi Arabia. This paper reports the frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the male and female population of A1-Ula in the northwestern province of Saudi Arabia. Phenotyping of G6PD revealed the presence of G6PD-Mediterranean, G6PDA+, G6PDA- and G6PD Mediterranean-like, and the frequency of these variants in Al-Ula was different from those reported in other regions of Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
Association of red cell glucose-6-phosphate dehydrogenase with haemoglobinopathies.
PMID 3699836 | DOI 10.1159/000153609 · Human heredity · 1986 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | G6PD | “A total of 1,112 randomly selected Saudi Arabs, of both sexes, living in Jeddah and the surrounding areas were screened for the phenotypic distribution of red cell glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD).” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “The results suggest that the red cell G6PD deficiency, sickle-cell and thalassaemia genes might have evolved as a result of the same ecological factor, probably malaria.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | thalassemia | “They were also investigated for haemoglobin and for thalassaemia.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | glucose-6-phosphate dehydrogenase deficiency | “A similar association was also observed between G6PD deficiency and thalassaemias in males (chi 2(1): alpha-thalassaemia - 3.13; beta-thalassaemia - 11.06) and females (chi 2(1): alpha-thalassaemia - 6.63).” | 0.93 | phenotype_alias_lexicon_v2 |