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GAPDH and Alzheimer disease are reported together in 3 articles.
Gene
GAPDH
- HGNC
- HGNC:4141
34articles
34mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Network pharmacology and molecular dynamic simulation integrated strategy for the screening of active components and mechanisms of phytochemicals from Datura innoxia on Alzheimer and cognitive decline.
PMID 38287491 | DOI 10.1080/07391102.2024.2308756 · Journal of biomolecular structure & dynamics · 2025 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “Based on the STRING and Cytoscape network-analysis platforms, the top ten anti-AD core targets include APP, CASP3, IL6, BACE1, IL1B, ACE, PSEN1, GAPDH, GSK3B and ACHE.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Alzheimer's disease (AD) ranks as the most prevalent neurodegenerative disorder with dementia and it accounts for more than 70% of all cases.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CASP3 | “Based on the STRING and Cytoscape network-analysis platforms, the top ten anti-AD core targets include APP, CASP3, IL6, BACE1, IL1B, ACE, PSEN1, GAPDH, GSK3B and ACHE.” | 0.98 | hgnc_dict_v1 |
| gene | BACE1 | “Based on the STRING and Cytoscape network-analysis platforms, the top ten anti-AD core targets include APP, CASP3, IL6, BACE1, IL1B, ACE, PSEN1, GAPDH, GSK3B and ACHE.” | 0.98 | hgnc_dict_v1 |
Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.
PMID 35458596 | PMCID PMC9025232 | DOI 10.3390/molecules27082398 · Molecules (Basel, Switzerland) · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “Among these 14 genes, GAPDH and AKT1 were the most significant.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | AKT1 | “Among these 14 genes, GAPDH and AKT1 were the most significant.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.” | 0.93 | phenotype_alias_lexicon_v2 |
Potential of Therapeutic Small Molecules in Apoptosis Regulation in the Treatment of Neurodegenerative Diseases: An Updated Review.
PMID 36364033 | PMCID PMC9654492 | DOI 10.3390/molecules27217207 · Molecules (Basel, Switzerland) · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “It has been demonstrated that several therapeutic agents including antioxidants, minocycline, GAPDH ligands, p53 inhibitors, JNK (c-Jun N-Terminal Kinase) inhibitors, glycogen synthase kinase-3 inhibitor, non-steroidal anti-inflammatory drugs, D2 dopamine receptor agonists, FK506, cell cycle inhibitors, statins, drugs targeting peroxisome proliferator-activated receptors, and gene therapy have the potential to provide protection to neurons against apoptosis.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Neurodegenerative disorders (NDs) include Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) and the common feature of NDs is the progressive death of specific neurons in the brain.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | amyotrophic lateral sclerosis | “Neurodegenerative disorders (NDs) include Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) and the common feature of NDs is the progressive death of specific neurons in the brain.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | Parkinson disease | “Neurodegenerative disorders (NDs) include Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) and the common feature of NDs is the progressive death of specific neurons in the brain.” | 0.93 | phenotype_alias_lexicon_v2 |