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GAPDH and breast cancer are reported together in 4 articles.
Gene
GAPDH
- HGNC
- HGNC:4141
34articles
34mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Cohesive data analysis for the identification of prognostic hub genes and significant pathways associated with HER2 + and TN breast cancer types.
PMID 40604083 | PMCID PMC12222827 | DOI 10.1038/s41598-025-94084-0 · Scientific reports · 2025 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Cohesive data analysis for the identification of prognostic hub genes and significant pathways associated with HER2 + and TN breast cancer types.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MCC | “Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).” | 0.98 | hgnc_dict_v1 |
| gene | ACTB | “Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).” | 0.98 | hgnc_dict_v1 |
In-vitro Cytotoxicity Investigations for Phytoconstituents of Saudi Medicinal Plants With Putative Ocular Effects.
PMID 38819027 | PMCID PMC11143859 | DOI 10.1177/15347354241256649 · Integrative cancer therapies · 2024 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “BEP-07 extract caused a significant decrease of survivin and increase in P27 expression compared to control GAPDH at its highest dose (14 µg/ml).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “BACKGROUND: Metastatic secondary ocular tumors spread from systemic malignancies, including breast cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “In-vitro Cytotoxicity Investigations for Phytoconstituents of Saudi Medicinal Plants With Putative Ocular Effects. This study aimed to evaluate the cytotoxicity of extracts from 5 medicinal plants native to Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
ONCOLYTIC ACTIVITY OF HUMAN ORTHOPNEUMOVIRUS IN CANCER CELL LINES.
PMID 35964639 | DOI 10.32471/exp-oncology.2312-8852.vol-44-no-2.18084 · Experimental oncology · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “The relative expression of apoptosis-related genes (CASP-3, -8, -9, Bax, Bcl-2, Bcl-XL, TP53, P21) during virus infection was estimated using rRT-PCR assay in comparison with the house-keeping gene (GAPDH).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “AIM: This study was designed to elucidate the possible role of hOPV in the modulation of cell growth and apoptosis in cancer cell lines including human epidermoid carcinoma (HEp-2), lung epithelial cell line (A549), and breast cancer cell line (MCF-7).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TP53 | “The relative expression of apoptosis-related genes (CASP-3, -8, -9, Bax, Bcl-2, Bcl-XL, TP53, P21) during virus infection was estimated using rRT-PCR assay in comparison with the house-keeping gene (GAPDH).” | 0.98 | hgnc_dict_v1 |
Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing.
PMID 29582634 | PMCID PMC5980855 | DOI 10.22034/APJCP.2018.19.3.777 · Asian Pacific journal of cancer prevention : APJCP · 2018 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “Methods: The siRNA targeting IL-10 and a glyceraldehyde 3-phosphate dehydrogenase (GAPDH) clone were introduced into MDA-MB-231 cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BAX | “IL-10 gene silencing causes down regulation of both PI3K/AKT and Bcl2 gene expression and also increases the Bbc3, BAX caspase3, and caspase 3 cleavage expression levels.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Real-time PCR assays were used to determine IL-10 and GAPDH gene expression levels, in addition to those for protein kinase B (AKT), phosphoinositide 3-kinase (PI3K), B-cell lymphoma 2 (Bcl2), caspase-3 and caspase-9 genes related to apoptosis.” | 0.98 | phenotype_alias_lexicon_v2 |